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Several myositis\u2010specific autoantibodies (MSAs) have been identified in IIMs and were found to be associated with distinct clinical features, including anti\u2010synthetase syndrome (ASyS) and immune\u2010mediated necrotizing myopathy (IMNM). Moreover, MSA\u2010related clinical features have been identified even within DM. Although MSAs are valuable for the diagnosis of IIMs, the pathogenic roles of these antibodies remain unknown. To investigate the pathogenesis of IIMs, classical murine models of autoimmune myositis, experimental autoimmune myositis, and C protein\u2010induced myositis have been established by immunization with muscle\u2010specific antigens, myosin, and myosin\u2010binding skeletal C protein, respectively. To according to MSA\u2010related autoimmunity, a murine model of ASyS was generated by immunization with a murine recombinant histidyl\u2010transfer RNA (tRNA) synthetase, Jo\u20101, in which muscle and lung inflammation are induced depending on acquired immunity. Furthermore, it was found that the transfer of human Immunoglobulin G (IgGs) from patients with IMNM, comprising anti\u2010signal recognition particles and anti\u20103\u2010hydroxy\u20103\u2010methylglutaryl coenzyme A reductase antibodies, induced complement\u2010mediated myositis in recipient mice. We found that CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010mediated myositis can be established depending on autoimmunity against transcriptional intermediary factor 1\u03b3 (TIF1\u03b3), an autoantigen for MSAs induced by recombinant human TIF1\u03b3 immunization. These new murine models reflecting MSA\u2010associated IIMs will reveal the immunological mechanisms underlying IIMs.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17142","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T04:43:29Z","timestamp":1707281009000},"page":"914-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Murine models of idiopathic inflammatory myopathies"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5398-0773","authenticated-orcid":false,"given":"Naoko","family":"Okiyama","sequence":"first","affiliation":[{"name":"Department of Dermatology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo 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