{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:31:32Z","timestamp":1787167892606,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epidural block using lidocaine, a non\u2010selective blocker of voltage\u2010gated sodium channels (Nav), has demonstrated efficacy in the treatment of severe plaque psoriasis in a limited number of cases. This study aimed to evaluate the effectiveness and safety of epidural lidocaine block in adult patients with severe, treatment\u2010resistant plaque psoriasis. This was an open\u2010label pilot study. Patients with severe plaque\u2010type psoriasis unresponsive to at least one systemic treatment were enrolled for a 1\u2010week epidural lidocaine block and followed up for 48\u2009weeks. Thirty\u2010six patients participated, with 32 completing the study. At the 12\u2010week mark, there was a remarkable 59% improvement in the mean Psoriasis Area Severity Index (PASI) score (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). By week 48, 28 out of 32 patients (87%) achieved PASI 75, while 18 out of 32 (56%) reached PASI 90. Within 7\u2009days, 20 out of 21 patients (95%) reported a reduction in itch, with a mean itch reduction of 82% at day 1 and 94% at day 7. Notably, no severe side effects were observed. Epidural lidocaine block proved to be an effective and safe long\u2010term treatment option for individuals with refractory severe plaque psoriasis.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17145","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:31:23Z","timestamp":1707870683000},"page":"696-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of epidural block with lidocaine for refractory severe plaque psoriasis: An open\u2010label pilot study in real world setting"],"prefix":"10.1111","volume":"51","author":[{"given":"Xin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain\u2010Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buwei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Ruijin Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youwen","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Beijing University of Chinese Medicine Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain\u2010Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain\u2010Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain\u2010Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5593-720X","authenticated-orcid":false,"given":"Qifang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain\u2010Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2019.07.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03829.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/64727"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70034-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1990.tb03825.x"},{"key":"e_1_2_8_7_1","first-page":"765","article-title":"Successful treatment of psoriasis vulgaris by epidural block: A case report","volume":"172","author":"Qifang L","year":"2020","journal-title":"Chin J Anesthesiol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.01.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415616964"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1246"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16012"},{"key":"e_1_2_8_12_1","first-page":"825","article-title":"Capsaicin\u2010loaded vesicular systems designed for enhancing localized delivery for psoriasis therapy","volume":"44","author":"Gupta R","year":"2016","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep13071340"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620040088028"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207488"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2247106"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05359.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/s23136065"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18044"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb05036.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39319"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13199"},{"key":"e_1_2_8_24_1","first-page":"783","article-title":"Posttraumatic reflex sympathetic dystrophy anteceding inverse psoriasis and psoriatic arthritis","volume":"22","author":"Conca W","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04612-3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007090105840"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13166"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218406"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000516"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.743675"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T09:39:57Z","timestamp":1714642797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/1346-8138.17145"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17145","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"2023-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}