{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:20:25Z","timestamp":1764782425714},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although AA amyloidosis is primarily caused by inflammatory conditions, associations between AA amyloidosis and solid cancers have occasionally been described. Herein, we report the case of a 48\u2010year\u2010old man in whom resection of a proliferating pilomatricoma with deposition of AA amyloid resulted in remission of concomitant AA gastrointestinal amyloidosis. A rapidly growing, giant, reddish, ulcerated tumor measuring 16\u2009\u00d7\u200913\u2009cm in size was identified on the upper left arm on a visit to our hospital. Gastrointestinal AA amyloidosis was diagnosed from colorectal mucosal biopsy at the same time, and weight loss and profuse diarrhea were clinically evident. As treatment, the tumor was resected with a 10\u2010mm surgical margin. Histologically, the tumor predominantly comprised a lobular proliferation of basophilic cells peripherally, filled with eosinophilic, cornified material and shadow cells with mitoses observed in basophilic cells. Specimens revealed eosinophilic, homogeneous deposits around tumor nests, which were confirmed as amyloid deposits by positive staining with Congo red stain. These deposits were immunohistochemically positive on staining with anti\u2010serum amyloid A antibody. Collectively, proliferating pilomatricoma with AA amyloidosis was diagnosed. After tumor resection, chronic diarrhea resolved and no amyloid deposition was apparent in colorectal biopsy. It is important to remember that if amyloid deposition is present in a tumor, aggressive tumor excision may alleviate systemic amyloidosis.<\/jats:p>","DOI":"10.1111\/1346-8138.17203","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T10:20:25Z","timestamp":1711362025000},"page":"1360-1363","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of <scp>AA<\/scp> amyloidosis complicated by proliferating pilomatricoma and a review of the literature"],"prefix":"10.1111","volume":"51","author":[{"given":"Koya","family":"Obara","sequence":"first","affiliation":[{"name":"Department of Dermatology Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Amoh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070265"},{"key":"e_1_2_6_3_1","first-page":"411","article-title":"Systemic amyloidosis and non\u2010hematologic malignancy in a large autopsy series","volume":"89","author":"Dictor M","year":"1981","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.19.6.539"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb01586.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb02191.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555570256259"},{"key":"e_1_2_6_8_1","first-page":"1769","article-title":"A clinico\u2010pathological study on cutaneous amyloidosis secondary to epidermal tumors","volume":"101","author":"Ichikawa H","year":"1991","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac217"},{"key":"e_1_2_6_10_1","first-page":"225","article-title":"Remission of nephrotic syndrome in amyloidosis associated with a hypernephroma","volume":"32","author":"Tang AL","year":"1989","journal-title":"Clin Nephrol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555563564567"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1996.tb04025.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-120022562"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801215)46:12<2693::AID-CNCR2820461226>3.0.CO;2-J"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T07:23:19Z","timestamp":1727940199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/1346-8138.17203"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17203","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"assertion":[{"value":"2023-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}