{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:36:12Z","timestamp":1774107372930,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023331","name":"LEO Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Small plaque psoriasis is the typical form of chronic plaque psoriasis affecting adults in South Korea. The effectiveness of calcipotriol\/betamethasone dipropionate (Cal\/BD) aerosol foam for large and small psoriasis plaques has not previously been examined. We performed a post hoc analysis of a recent, 4\u2010week observational study of Cal\/BD aerosol foam use in routine clinical practice in South Korea. Investigator Global Assessment response ([IGA] 0\/1 at week 4), Patient Global Assessment response ([PaGA] 0\/1 at week 4), change in Psoriasis Area and Severity Index (PASI), changes in psoriasis symptom scores, change in the Dermatology Life Quality Index (DLQI), and the proportion of patients achieving DLQI \u22645 were analyzed for patients with small (\u22645\u2009cm;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009131) or large (&gt;5\u2009cm;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200935) baseline plaque size. IGA response rates were similar for patients with small and large plaques (59.5% and 51.4% respectively). Similarly, there was no significant difference between the small and large groups in mean change in PASI (\u22122.20 vs \u22123.34), the proportions of patients with DLQI \u22645 (62.3% vs 54.3%) or PaGA 0\/1 (29.2% vs 40.0%). Mean improvements in DLQI (\u22124.04 vs \u22126.20) and in psoriasis symptoms including itching (\u22121.50 vs \u22122.83), sleep loss (\u22120.67 vs \u22121.89), dryness (\u22121.57 vs \u22122.97), scaling (\u22121.21 vs \u22123.57), and redness (\u22121.17 vs \u22123.11) were greater in patients with large plaques than those with small plaques. Itching and DLQI differences were not statistically significant after adjustment for baseline characteristics. Stratification by body surface area affected eliminated statistically significant differences between the groups for most outcomes. In conclusion, this analysis suggests that Cal\/BD aerosol foam is an effective, well\u2010accepted treatment for adult patients with the small plaques typical of chronic plaque psoriasis in South Korea, as well as for those with large plaques.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17253","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T04:59:30Z","timestamp":1715144370000},"page":"1010-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of calcipotriol\/betamethasone dipropionate aerosol foam in patients with small versus large plaque psoriasis in routine practice in South Korea"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-7672","authenticated-orcid":false,"given":"Seong Jin","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Dermatology Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul\u2010Jong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bucheon St. Mary's Hospital The Catholic University of Korea  Bucheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-0331","authenticated-orcid":false,"given":"Chul Hwan","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Heon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Dermatology KyungHee University Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Seok","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chosun University Hospital  Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-2400","authenticated-orcid":false,"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHA Bundang Medical Center, CHA University School of Medicine  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-3869","authenticated-orcid":false,"given":"Hae Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chungnam National University Sejong Hospital  Sejong South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YoungEun","family":"Kim","sequence":"additional","affiliation":[{"name":"LEO Pharma Limited  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun","family":"Choi","sequence":"additional","affiliation":[{"name":"LEO Pharma Limited  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-3530","authenticated-orcid":false,"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seongnam South Korea"},{"name":"Department of Dermatology Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.378"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0007-0963.2004.05891.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2877"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14513"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14943"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14617"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17084"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15077"},{"key":"e_1_2_8_11_1","article-title":"A real\u2010world, observational study on the effectiveness with calcipotriol\/betamethasone aerosol foam in patients with plaque psoriasis in Greece: the CELSUS study","volume":"35","author":"Rigopoulos D","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16519"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15089"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23621.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417743234"}],"container-title":["The Journal of 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