{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:29:44Z","timestamp":1780756184632,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Onychomycosis is a chronic and intractable disease whose prevalence increases during aging. In elderly patients, if onychomycosis is left untreated and progresses to a severe stage it may cause functional decline of the lower limbs due to foot pain. This could lead to a decline in activities of daily living and secondary impairment such as cognitive decline. Thus, the treatment of onychomycosis in elderly patients is important. We have previously shown that fosravuconazole is relatively safe and effective for onychomycosis in elderly patients. In the present study, we continued the follow\u2010up study and investigated the efficacy of re\u2010administration of fosravuconazole in patients with recurrent onychomycosis. One hundred and twenty\u2010five patients aged \u226565\u2009years who had been initially diagnosed with onychomycosis at our hospital's dermatology department, and who had responded well to fosravuconazole at 48\u2009weeks after the initial treatment, were followed up until 144\u2009weeks after the start of the initial treatment. Patients who experienced a recurrence within 24\u2009weeks after the start of the follow\u2010up were assigned to the short\u2010term recurrence group, and those who experienced a recurrence after 24\u2009weeks were assigned to the long\u2010term recurrence group. All patients in both groups were re\u2010treated with fosravuconazole to evaluate its efficacy. The short\u2010term and long\u2010term recurrence groups consisted of 17 (14.3%) and 10 (8.4%) patients, respectively. There were no significant differences in mean age and sex ratio between the two groups. There were no serious adverse effects in either group, and the toenail opacity ratio was significantly reduced after 12\u2009weeks of re\u2010treatment in both groups. The short\u2010term and long\u2010term recurrence groups were significantly more likely to have wedge\u2010shaped onychomycosis and total dystrophic onychomycosis, respectively. The results suggest that re\u2010administration of fosravuconazole is safe and as effective as the first administration for elderly patients with recurrent onychomycosis. This study was registered at UMIN\u2010CTR (UMIN000053516).<\/jats:p>","DOI":"10.1111\/1346-8138.17254","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T12:34:37Z","timestamp":1714739677000},"page":"1091-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term follow\u2010up study of the efficacy of fosravuconazole in the treatment of onychomycosis in elderly patients"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1766-2013","authenticated-orcid":false,"given":"Ayaka","family":"Okubo","sequence":"first","affiliation":[{"name":"Department of Dermatology Muroran City General Hospital  Muroran\u2010shi Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miharu","family":"Hanada","sequence":"additional","affiliation":[{"name":"Department of Nursing Muroran City General Hospital  Muroran\u2010shi Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Nursing Muroran City General Hospital  Muroran\u2010shi Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeko","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Muroran City General Hospital  Muroran\u2010shi Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Diabetes Muroran City General Hospital  Muroran\u2010shi Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"27","article-title":"Large\u2010scale epidemiological survey of actual and potential incidence of tinea pedis and onychomycosis (Foot Check 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