{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:30:59Z","timestamp":1789086659116,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Most clinical trials investigating targeted therapies for patients harboring <jats:italic>BRAF<\/jats:italic> V600 mutations have included mostly White patients, and data for Asian patients are scarce. Although there are several retrospective studies in Japanese patients, they have investigated only the dabrafenib\u2009+\u2009trametinib regimen, and have had a short follow\u2010up period. We conducted a single\u2010center retrospective study to update previous studies and compare the outcomes with those in White patients. We analyzed 89 patients who received dabrafenib\u2009+\u2009trametinib or encorafenib\u2009+\u2009binimetinib, including 11 who received both treatment regimens. The overall response rate was 79.8%, with complete response in 25 patients (28.1%) and partial response in 45 patients (51.7%). The median progression\u2010free survival was 13.7\u2009months, and the median overall survival was 32.9\u2009months. The 3\u2010year progression\u2010free and overall survival rates were 31.8% and 47.9%, respectively. Although the two regimens showed no significant differences in efficacy, their safety profiles differed, as reported in clinical trials. Therefore, the most frequent adverse event associated with the dabrafenib\u2009+\u2009trametinib regimen was pyrexia (61.3%) and that of encorafenib\u2009+\u2009binimetinib was blurred vision (32.0%). Switching directly to another targeted therapy after progressive disease showed no clinical response; however, rechallenge followed by immune checkpoint inhibitor therapy showed a certain response. As a prognostic factor, performance status was associated with progression\u2010free survival, and performance status, serum lactate dehydrogenase level, and dose interruption were associated with overall survival in the multivariate analysis. Real\u2010world data on targeted therapy for patients with melanoma in Japan suggest that both dabrafenib\u2009+\u2009trametinib and encorafenib\u2009+\u2009binimetinib show similar efficacy and safety in Asian and White patients.<\/jats:p>","DOI":"10.1111\/1346-8138.17263","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T08:59:30Z","timestamp":1715158770000},"page":"1199-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010world efficacy and safety of <scp>BRAF<\/scp>\u2010targeted therapy for patients with advanced melanoma: A single\u2010center retrospective study in Japan"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-8182","authenticated-orcid":false,"given":"Eiji","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo 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