{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:45:34Z","timestamp":1792003534423,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies indicate that hepatic diseases are associated with psoriasis. Non\u2010invasive tests, including the Fibrosis\u20104 (FIB\u20104) index, which can confidently rule out the presence of advanced fibrosis, are currently receiving attention. However, data on the FIB\u20104 index in psoriasis patients and the effects of biologics on the FIB\u20104 index are limited. We investigated the relationships between the FIB\u20104 index and demographic or clinical characteristics as well as the effects of biologics on the FIB\u20104 index in psoriasis patients. Psoriasis patients aged 36\u201364\u2009years, whose treatment was initiated with interleukin (IL)\u201017 inhibitors or IL\u201023 inhibitors for psoriasis from May 2015 to December 2022, were consecutively included. Data were collected retrospectively from the patients' charts. A total of 171 psoriasis patients were included in this study. Thirty\u2010four, 43, 21, 32, and 41 psoriasis patients were treated with secukinumab, ixekizumab, brodalumab, guselkumab, or risankizumab, respectively. In biologics\u2010na\u00efve patients, a significant but weak positive correlation was observed between the FIB\u20104 index and age (<jats:italic>r<\/jats:italic>\u2009=\u20090.3246, <jats:italic>p<\/jats:italic>\u2009=\u20090.0018). There was no significant correlation between the FIB\u20104 index and other demographic or clinical characteristics. Regarding the effects of biologics on the FIB\u20104 index, no significant change was observed in psoriasis patients treated with any biologics. However, in psoriasis patients with a baseline FIB\u20104 index of &gt;1.3, patients treated with guselkumab and those treated with either IL\u201023 inhibitor showed significantly decreased FIB\u20104 index scores 6\u2009months after initiating the biologics (<jats:italic>p<\/jats:italic>\u2009=\u20090.0323, <jats:italic>p<\/jats:italic>\u2009=\u20090.0212). In contrast, no change was observed in FIB\u20104 index scores in patients treated with IL\u201017 inhibitors. In conclusion, our study revealed that the FIB\u20104 index was correlated with age in psoriasis patients. Furthermore, IL\u201023 inhibitors (but not IL\u201017 inhibitors) decreased the FIB\u20104 index score at 6\u2009months in psoriasis patients with elevated FIB\u20104 index scores at baseline. Further studies are needed to clarify whether IL\u201023 inhibitors improve liver fibrosis physiologically and functionally.<\/jats:p>","DOI":"10.1111\/1346-8138.17277","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T10:23:38Z","timestamp":1716891818000},"page":"1216-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Interleukin\u201023 inhibitors decrease Fibrosis\u20104 index in psoriasis patients with elevated Fibrosis\u20104 index but not interleukin\u201017 inhibitors"],"prefix":"10.1111","volume":"51","author":[{"given":"Ryosuke","family":"Takeshima","sequence":"first","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo 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