{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:54:30Z","timestamp":1778950470375,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor characterized by a high risk of local recurrence but a low risk of metastasis. Wide local excision (WLE) has been an important treatment option, but its clinical outcomes and safety have not been thoroughly evaluated in previous reports. The aim of this study was to determine appropriate surgical margins (deep and lateral) and prognostic factors associated with recurrence\u2010free survival (RFS) of DFSP. A database collected by two dermatology departments in Japan was retrospectively reviewed to identify 116 patients with DFSP who underwent complete resection with WLE between 1994 and 2021. Sixty\u2010one men (53%) and 55 women (47%) were included in our cohort. The primary sites of DFSP were as follows: 11 head and neck (9%); seven face (7%); 12 upper extremities (10%); 20 lower extremities (17%); and 66 trunk (57%). There were 103 cases (89%) of primary DFSP and 13 cases (11%) of recurrent DFSP. Total 10\u2010year RFS was 96.6%. There were significant differences in RFS by tumor size (median size: 3\u2009cm), disease status (primary versus recurrent DFSP), and fibrosarcomatous change (positive versus negative) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Two patients (1.7%) with buccal or head lesions had positive deep margins. In all cases, the lateral margin was negative at the postoperative evaluation. Tumor size, disease status, and fibrosarcomatous change are important risk factors for recurrence. Both face and head\u2013neck lesions were more likely to have positive deep margins than other anatomic areas in DFSP. Although this study was limited by its retrospective design, a narrow 2\u2010cm lateral margin is especially considered for low\u2010risk patients.<\/jats:p>","DOI":"10.1111\/1346-8138.17280","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T10:24:36Z","timestamp":1716373476000},"page":"1225-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of surgical margins and prognostic factors in dermatofibrosarcoma protuberans after wide local excision: A\u00a0multicenter study of 116 Japanese patients"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-2786","authenticated-orcid":false,"given":"Yusuke","family":"Muto","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai 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Hospital  Chuo City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-8182","authenticated-orcid":false,"given":"Eiji","family":"Nakano","sequence":"additional","affiliation":[{"name":"Dermatologic Oncology National Cancer Center Hospital  Chuo City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Jinnai","sequence":"additional","affiliation":[{"name":"Dermatologic Oncology National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3866-5609","authenticated-orcid":false,"given":"Yumi","family":"Kambayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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