{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:11:19Z","timestamp":1781921479877,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273540"],"award-info":[{"award-number":["82273540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lupus erythematosus panniculitis (LEP) is a chronic inflammatory skin disease with a significant impact on the overall well\u2010being of patients. The safety and efficacy of oral baricitinib for the treatment of LEP have not been studied. This study aimed to explore the efficacy of oral baricitinib in patients with LEP who are recalcitrant or intolerant to conventional therapies. Patients (aged \u226518\u2009years) with active LEP (with a revised cutaneous lupus erythematosus disease area and severity index [RCLASI]\u2010active score\u2009\u22654] were randomly assigned 2:1 to baricitinib (4\u2009mg) or placebo (once daily for 20\u2009weeks). The placebo group was switched to baricitinib (4\u2009mg) at week 13, and the final evaluation was conducted at week 24. The primary endpoint was the proportion of patients with an RCLASI\u2010A\u2009score decreased by 20% at week 12. The secondary endpoints included the changes in the Cutaneous Lupus Erythematosus Disease Area and Severity Index active\u2010(CLASI\u2010A) score, the Dermatology Life Quality Index (DLQI), the Physician's Global Assessment (PGA) score, and safety. Five patients were enrolled. Three patients received baricitinib (4\u2009mg), and two patients were treated with placebo. Two patients in the baricitinib treatment group showed a significant RCLASI\u2010A decrease at week 12 and week 24. Two patients in the placebo group had no change in RCLASI\u2010A at week 12 and a significant decrease at week 24. No new safety events were observed. Treatment with baricitinib was effective and well tolerated in patients with LEP.<\/jats:p>","DOI":"10.1111\/1346-8138.17354","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:30:07Z","timestamp":1721388607000},"page":"1434-1440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A double\u2010blind pilot study of oral baricitinib in adult patients with lupus erythematosus panniculitis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-0197","authenticated-orcid":false,"given":"Jingjing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Allergy and Rheumatology, Hospital of Dermatology (Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Hospital of Dermatology (Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5169-2751","authenticated-orcid":false,"given":"Liangchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Xiangya Hospital of Central South University, Institute of Dermatology and Venereology of Central South University Hunan Clinical Medicine Research Center for Major Skin Diseases and Skin Health  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Trials and Cosmetics Testing Center, Hospital for Skin Diseases (Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Hospital of Dermatology (Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-4897","authenticated-orcid":false,"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology (Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing Jiangsu China"},{"name":"Key Laboratory of Basic and Translational Research on Immune\u2010Mediated Skin Diseases Chinese Academy of Medical Sciences  Nanjing Jiangsu 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