{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:19:18Z","timestamp":1789957158125,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Whether clinical and genetic markers can be used to differentiate patients with varying responses to different psoriasis therapies needs to be elucidated. Here, we assess whether human leukocyte antigen C (HLA\u2010C)*06:02 is associated with response to biologics. Response to treatment was defined as a Psoriasis Area and Severity Index score of \u22642 (PASI\u2264\u20092) after 3 months. In total, 648 patients with psoriasis initiating treatment with biologics were included; 289 were HLA\u2010C*06:02 positive and 359 were HLA\u2010C*06:02 negative. Patients were treated with tumor necrosis factor (TNF) inhibitors (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009469), interleukin (IL)\u201012\/23 inhibitors (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200992), IL\u201017 inhibitors (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200978), and IL\u201023 inhibitors (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099). Significantly more patients positive for HLA\u2010C*06:02 achieved PASI\u2264\u20092 compared with patients negative for HLA\u2010C*06:02 when treated with IL\u201012\/23 inhibitors. There was no significant difference between response in HLA\u2010C*06:02 positive and negative patients for TNF inhibitors or IL\u201017 inhibitors. No analyses were conducted for IL\u201023 inhibitors because of the limited number of patients. The data confirm that HLA\u2010C*06:02 may be used as a biomarker for response to anti\u2010IL12\/23 treatment.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17415","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T06:39:59Z","timestamp":1724740799000},"page":"142-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>HLA<\/scp>\n                    \u2010C*06:02 in Danish patients with psoriasis and response to biological treatment"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-9644","authenticated-orcid":false,"given":"Mie Siewertsen","family":"Bergmann","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-3280","authenticated-orcid":false,"given":"Nikolai","family":"Loft","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Willy","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diljit","family":"Kaur\u2010Knudsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev and Gentofte  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"Systemic pharmacological treatments for chronic plaque psoriasis: a network meta\u2010analysis (review)","volume":"7","author":"Sbidian E","year":"2020","journal-title":"Cochrane Libr"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21677"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3722"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0098"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18870"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.038"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad481"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2020.1684472"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.055"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-017-0261-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2021.1862082"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.17415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T13:44:55Z","timestamp":1773582295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/1346-8138.17415"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17415","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,27]]},"assertion":[{"value":"2024-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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