{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:10:04Z","timestamp":1791817804510,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to analyze the clinical profile and malignancy indicators in dermatomyositis (DM) with anti\u2010transcriptional intermediary factor 1 antibody (anti\u2010TIF1\u03b3\u2010Ab). A comparison was made between clinical information of anti\u2010TIF1\u03b3 DM patients with and without malignancy. Additionally, a review of the literature on anti\u2010TIF1\u03b3 DM and malignancy was conducted by searching PubMed and EMBASE databases. In our cohort of 37 patients, 27.0% (10\/37) developed malignancy. The timeframe during which these 10 patients developed malignancy ranged from 21\u2009months prior to the diagnosis of DM to 36\u2009months following the diagnosis of DM. Specifically, one patient was diagnosed with breast cancer at the age of 36. Comparing the groups with and without malignancy, we found that age over 65\u2009years (40% vs 7.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.035), a shorter duration from the onset of symptoms to the diagnosis of DM (2.5 vs 10\u2009months, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), and higher erythrocyte sedimentation rate (ESR) levels (23 vs 10\u2009mm\/h, <jats:italic>P<\/jats:italic>\u2009=\u20090.048) were found to be associated with an increased risk of malignancy. Conversely, the presence of Gottron's papules (63% vs 20%, <jats:italic>P<\/jats:italic>\u2009=\u20090.029) may suggest a lower likelihood of malignancy. The literature review revealed that the prevalence of myositis\u2010associated malignancy was 40.7% (340\/836), with variations ranging from 19% to 82.9% across different series. In summary, factors such as age over 65\u2009years, a shorter duration between symptom onset and diagnosis of DM, and elevated ESR levels may indicate an increased risk of malignancy in anti\u2010TIF1\u03b3 DM patients.<\/jats:p>","DOI":"10.1111\/1346-8138.17426","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T13:26:15Z","timestamp":1726061175000},"page":"1646-1657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and laboratory features between anti\u2010<scp>TIF1\u03b3<\/scp> dermatomyositis with and without malignancy: 37 case series and a review"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-2648","authenticated-orcid":false,"given":"Ke\u2010yun","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5065-4086","authenticated-orcid":false,"given":"Han\u2010lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale School of Medicine  Connecticut New Haven USA"},{"name":"Department of Cellular &amp; Molecular Physiology Yale School of Medicine  Connecticut New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-1554","authenticated-orcid":false,"given":"Hong\u2010zhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing 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