{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:28:21Z","timestamp":1785554901279,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J01770"],"award-info":[{"award-number":["2021J01770"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01675"],"award-info":[{"award-number":["2023J01675"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2022CXA013"],"award-info":[{"award-number":["2022CXA013"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Observational studies have suggested an associations between hidradenitis suppurativa (HS) and metabolic syndrome (MetS) and its components. However, it remains unclear whether the relationship is causal or not. Our study aimed to investigate the causal association of HS with MetS and its components. We performed a bidirectional, two\u2010sample Mendelian randomization study using summary\u2010level data from the most comprehensive genome\u2010wide association studies of HS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009362\u2009071), MetS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009291\u2009107), waist circumference (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009462\u2009166), hypertension (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009463\u2009010) fasting blood glucose (FBG,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009200\u2009622), triglycerides (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009441\u2009016), and high\u2010density lipoprotein cholesterol (HDL\u2010C,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009403\u2009943). Genetic instrumental variables were constructed by identifying single nucleotide polymorphisms associated with the corresponding factors. The random\u2010effects inverse\u2010variance weighted method was applied as the primary method. The results showed that genetically predicted HS was positively associated with waist circumference risk in both directions. High waist circumference increased the risk of HS (odds ratio [OR] 4.147; 95% confidence interval [CI] 2.610\u20136.590;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.746\u2009\u00d7\u200910\n                    <jats:sup>\u22129<\/jats:sup>\n                    ). In addition, HS was also affected by waist circumference (OR 1.009; 95% CI 1.006\u20131.012;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20093.08\u2009\u00d7\u200910\n                    <jats:sup>\u22127<\/jats:sup>\n                    ). No causal relationships were found between HS and MetS or its components other than waist circumference. The findings highlight the importance of early intervention for obesity in HS patients. Further studies are needed to determine the pathophysiology of HS associated with MetS and its components.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17436","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T04:44:45Z","timestamp":1725425085000},"page":"155-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of hidradenitis suppurativa (\n                    <scp>HS<\/scp>\n                    ) with waist circumference: A bidirectional two\u2010sample Mendelian randomization study of\n                    <scp>HS<\/scp>\n                    with metabolic syndrome"],"prefix":"10.1111","volume":"52","author":[{"given":"Huaiyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, the Union Hospital Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Union Hospital Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Union Hospital Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-7095","authenticated-orcid":false,"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Union Hospital Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Union Hospital Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Union Hospital Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Union Hospital Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-3534","authenticated-orcid":false,"given":"Xuemin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Union Hospital Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2023.08.020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77184-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14500"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu328"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx034"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14024"},{"key":"e_1_2_7_9_1","article-title":"Causal effect of elevated body mass index on hidradenitis suppurativa: a two\u2010sample Mendelian randomization study","volume":"4","author":"Xu Y","year":"2023","journal-title":"Br J 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