{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:42:44Z","timestamp":1792190564371,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015661","name":"UCB Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bimekizumab treatment has demonstrated significant improvements in clinical outcomes in patients with moderate to severe plaque psoriasis; however, studies so far have focused on predominantly White patient populations from North America and Europe, with one smaller study in a Japanese population. Here, clinical responses, safety, and tolerability of bimekizumab treatment in Korean patients are reported. Korean patients with moderate to severe plaque psoriasis were randomized to bimekizumab 320\u2009mg every 4\u2009weeks (Q4W) or placebo Q4W to week 16. Co\u2010primary efficacy end points were achievement of \u226590% improvement from baseline in the Psoriasis Area and Severity Index (PASI 90) and Investigator's Global Assessment score of 0\/1 (clear\/almost clear) at week 16. Secondary efficacy end points included achievement of PASI 75 at week 4 and Dermatology Life Quality Index 0\/1 at week 16. Safety outcomes were also assessed. Statistical analysis of the co\u2010primary efficacy end points was performed using a type I error rate, at a two\u2010sided \u03b1 level of 0.05. Overall, 47 Korean patients were randomized to treatment (bimekizumab: 32, placebo: 15). At week 16, bimekizumab\u2010treated patients had significantly higher clinical responses versus placebo\u2010treated patients (PASI 90: 81.3% vs. 0%; IGA 0\/1: 87.5% vs. 0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for both). Bimekizumab showed a rapid onset of clinical response, with 75.0% of patients achieving PASI 75 by week 4 (0% in placebo patients [nominal <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]). A higher proportion of bimekizumab\u2010treated patients achieved DLQI 0\/1 at week 16 (46.9% vs. 6.7% in placebo patients, nominal <jats:italic>p<\/jats:italic>\u2009=\u20090.007), indicating greater improvements in health\u2010related quality of life (HRQoL) following bimekizumab treatment. Bimekizumab was well\u2010tolerated in Korean patients, with no new safety signals identified. Treatment with bimekizumab led to rapid improvements in clinical responses and HRQoL versus placebo in Korean patients, consistent with responses in global populations. These findings suggest that bimekizumab is an effective and well\u2010tolerated treatment option in Korean patients with psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.17446","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T09:04:10Z","timestamp":1727427850000},"page":"1392-1403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bimekizumab efficacy and safety in Korean patients with moderate to severe plaque psoriasis: A phase 3, randomized, placebo\u2010controlled, double\u2010blinded study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-3530","authenticated-orcid":false,"given":"Sang Woong","family":"Youn","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-7672","authenticated-orcid":false,"given":"Seong Jin","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Jong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bucheon St.\u00a0Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Seok","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chosun University Hospital  Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Heon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyung Hee University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Hwan","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul St Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Cross","sequence":"additional","affiliation":[{"name":"UCB Pharma  Morrisville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Thirlwell","sequence":"additional","affiliation":[{"name":"Allegis Group  Bracknell UK"},{"name":"UCB Pharma  Slough 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