{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T15:28:01Z","timestamp":1773588481988,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intravenous corticosteroid pulse therapy (IVPT) has been preferentially conducted for rapidly progressive alopecia areata (RP\u2010AA); however, the evaluation of long\u2010term outcomes has been insufficient. In this study, 106 IVPT\u2010treated RP\u2010AA patients (36 males and 70 females) who were followed up for more than 1\u2009year and up to 6.8\u2009years were retrospectively analyzed. The mean observation period was 1137.8\u2009\u00b1\u2009587.9\u2009days (range 380\u20132490). The mean severity of alopecia tool (SALT) score before IVPT was 21.3\u2009\u00b1\u200923.4 but whole\u2010scalp hair loss was observed in all cases after the intervention, suggesting that IVPT was performed soon after the onset. With additional interventions represented by intralesional triamcinolone acetonide injection with or without topical potent corticosteroid for those who insufficiently responded at 6\u2009months after IVPT, 64.2%, 14.2%, and 21.7% of the patients respectively achieved good response (GR; SALT score\u2009\u226425), moderate response (MR; 25\u2009&lt;\u2009SALT score\u2009&lt;75), and poor response (PR; 75\u2009\u2264\u2009SALT score) 1\u2009year after IVPT. On the final evaluation, the proportions of patients with GR, MR, and PR were 79 (74.5%), 7 (6.6%), and 20 (18.9%). Sixteen patients achieved and maintained full hair regrowth with IVPT alone until the end of observation. A previously reported scoring system for the short\u2010term outcome prediction was shown to be useful for distinguishing the final\u2010point GR responders from PR responders (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.003). Of note, 21 patients were found to have some symptoms suggestive of the existence of preceding infectious diseases and tended to relapse. The revised scoring system adding the absence of preceding infectious diseases as one factor successfully predicted the occurrence of the relapse in our cohort (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002). Taken together, previously unreported real\u2010world efficacy of IVPT to RP\u2010AA was elucidated with the invention of a tool putatively enabling optimal long\u2010term management.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17506","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T08:39:34Z","timestamp":1728895174000},"page":"112-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term outcomes of intravenous corticosteroid pulse therapy for rapidly progressive alopecia areata: A single\u2010center retrospective analysis of 106 cases and usefulness evaluation of a scoring system originally designed for half\u2010year efficacy prediction for extended periods"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-4127","authenticated-orcid":false,"given":"Masahiro","family":"Fukuyama","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Kyorin University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-6663","authenticated-orcid":false,"given":"Misaki","family":"Kinoshita\u2010Ise","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Kyorin University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-5717","authenticated-orcid":false,"given":"Manabu","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Kyorin University  Tokyo 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