{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:44:21Z","timestamp":1791902661081,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This subgroup analysis of the ALLEGRO phase 2b\/3 study (NCT3732807) assessed the efficacy and safety of multiple doses of ritlecitinib, an oral JAK3\/TEC family kinase inhibitor, in Asian patients with alopecia areata (AA). Patients aged \u226512\u2009years with AA and \u226550% scalp hair loss received once\u2010daily ritlecitinib 50 or 30\u2009mg (with or without 4\u2010week 200\u2010mg loading dose [\u201c200\/50\u201d or \u201c200\/30\u201d]) or 10\u2009mg or placebo for 24\u2009weeks, followed by a 24\u2010week extension, in which patients initially assigned to placebo switched to 200\/50 or 50\u2009mg. In this subgroup analysis, Asian patients with response based on achieving a Severity of Alopecia Tool (SALT) score \u226420, SALT \u226410, \u22652\u2010grade improvement or normal score on the eyebrow assessment (EBA) scale, and \u22652\u2010grade improvement or normal score on the eyelash assessment (ELA) scale were evaluated through week 48. Safety was monitored throughout. In total, 186 Asian patients were randomized to ritlecitinib 200\/50\u2009mg (<jats:italic>n<\/jats:italic>\u2009=\u200933), 200\/30\u2009mg (<jats:italic>n<\/jats:italic>\u2009=\u200928), 50\u2009mg (<jats:italic>n<\/jats:italic>\u2009=\u200943), 30\u2009mg (<jats:italic>n<\/jats:italic>\u2009=\u200934), 10 mg (<jats:italic>n<\/jats:italic>\u2009=\u200917), placebo to 200\/50\u2009mg (<jats:italic>n<\/jats:italic>\u2009=\u200914), or placebo to 50\u2009mg (<jats:italic>n<\/jats:italic>\u2009=\u200917). The proportions of patients treated with ritlecitinib \u226530\u2009mg achieving a SALT score \u226420 response were 9.1%\u201336.4% at week 24 vs 0% for the 10\u2010mg group and 3.2% for placebo. At week 48, 26.5%\u201355.6% of patients treated with ritlecitinib \u226530\u2009mg achieved a SALT \u226420 response. At week 48, the proportions of patients treated with ritlecitinib \u226530\u2009mg with EBA response were 41.9%\u201371.1% and with ELA response were 40.7%\u201357.9%. The most common adverse events were nasopharyngitis, folliculitis, upper respiratory tract infection, and urticaria. No serious or opportunistic infections, major adverse cardiovascular events, thromboembolic events, malignancies, or deaths were reported. Ritlecitinib demonstrated clinical efficacy and acceptable safety over 48\u2009weeks in Asian patients \u226512\u2009years with AA and \u226550% hair loss. Results for the Asian subpopulation were consistent with the overall population in the ALLEGRO\u20102b\/3 study.<\/jats:p>","DOI":"10.1111\/1346-8138.17539","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T11:40:13Z","timestamp":1741779613000},"page":"603-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of ritlecitinib in Asian patients with alopecia areata: A subgroup analysis of the <scp>ALLEGRO<\/scp> phase 2b\/3 trial"],"prefix":"10.1111","volume":"52","author":[{"given":"Xingqi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital, Sun Yat\u2010Sen 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