{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:05Z","timestamp":1790281745173,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bullous pemphigoid (BP) is the most prevalent autoimmune blistering disorder, triggered by autoantibodies targeting hemidesmosome components. It is associated with substantial morbidity and increased mortality. No studies comprehensively evaluate all comorbidities before and after diagnosing patients with BP. We aimed to investigate all BP\u2010associated comorbid diseases and their patterns of associations. This nationwide population\u2010based study included 5066 patients with BP and 10\u2009132 controls between 2011 and 2021. We performed an automated mass screening of 546 diagnostic codes to identify BP\u2010associated comorbidities 5\u2009years before and after BP diagnosis, and analyzed associations patterns of comorbidities. Patients with BP had increased odds of having pressure ulcers, intracerebral hemorrhage, scabies, neuropsychiatric disorders, psoriasis, drug eruption, and acute renal failure before BP diagnosis. After BP diagnosis, they had increased odds pneumonia, sepsis, chronic renal disease, and cardiac arrest. Strong interrelationships were observed between five neuropsychiatric conditions before BP diagnosis and a strong bidirectional association between Alzheimer's dementia and pneumonia after BP diagnosis. This large case\u2013control study of patients with BP thoroughly identified all relevant comorbidities before and after BP diagnosis, highlighting their clinical significance as predisposing and prognostic factors in patients with BP.<\/jats:p>","DOI":"10.1111\/1346-8138.17577","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T07:13:51Z","timestamp":1734074031000},"page":"460-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comorbid diseases in bullous pemphigoid: A population\u2010based case\u2013control study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-1606","authenticated-orcid":false,"given":"Bo Ri","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4073-6428","authenticated-orcid":false,"given":"Kun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Applied Statistics Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-2371","authenticated-orcid":false,"given":"Kyungho","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-4539","authenticated-orcid":false,"given":"Minjae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-8519","authenticated-orcid":false,"given":"Jung Min","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St Vincent's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-8819","authenticated-orcid":false,"given":"Chong Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-3530","authenticated-orcid":false,"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22538.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00238"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S267573"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/ddg.14738","article-title":"Comorbid diseases among bullous pemphigoid patients in Germany: new insights from a case\u2010control study","volume":"20","author":"Martin E","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17121"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.052"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37125"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(80)80247-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(87)90051-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb01447.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555576497498"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1925"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/90922"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09350.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-04-0309"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.322"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.357"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12995"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15405"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106574"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.12997\/jla.2022.11.2.103"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004273"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1032-6"},{"key":"e_1_2_9_25_1","first-page":"636","article-title":"Discovery of association rules patterns and prevalence of comorbidities in adult patients hospitalized with mental and behavioral disorders","volume":"9","author":"Cha S","year":"2021","journal-title":"Dent Health"},{"key":"e_1_2_9_26_1","first-page":"9","article-title":"Using association rules to measure subjective organization after acquired brain injury","volume":"42","author":"Parente F","year":"2018","journal-title":"NeuroRehabilitation"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70062-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2005.11.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20549"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315393"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15375"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13031"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12132"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00719-7"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010328"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10972"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.1587"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3457"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16948"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1111\/ddg.15219","article-title":"Association between chronic kidney disease and risk of bullous pemphigoid: a nationwide population\u2010based cohort study","volume":"21","author":"Yu WT","year":"2023","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9695-9"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00479"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1155181"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(94)00371-K"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142516"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.0805"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754211035124"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T13:23:07Z","timestamp":1747660987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,13]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/1346-8138.17577"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17577","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,13]]},"assertion":[{"value":"2024-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}