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This review aimed to evaluate the relationship of peripheral blood inflammatory markers such as erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP), neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), monocyte\u2010to\u2010lymphocyte ratio (MLR), pan\u2010immune\u2010inflammation value (PIV) and systemic immune\u2010inflammation index (SII) with the presence and severity of HS. A comprehensive search of the PubMed, Embase and Cochrane databases was conducted. Studies with data on these peripheral blood inflammatory markers in HS patients were included. A meta\u2010analysis was performed using standardized mean differences to evaluate the association between these inflammatory markers and HS. Our study included 23 research articles that included 2623 cases and 22\u2009015 controls. The results demonstrated that (1) CRP, ESR, NLR, and SII levels were significantly higher in HS patients than controls, and (2) CRP, ESR, PIV, and SII positively correlated with HS severity between Hurley stages I and II and II and III. NLR and PLR also correlated with severity between stages II and III. CRP, ESR, NLR and SII are significantly associated with the presence of HS, while CRP, ESR, SII, and PIV are important indicators of HS severity. NLR and PLR become particularly significant in groups with severe HS. Our results underscore the systemic inflammatory involvement in HS and suggest that these inflammatory markers could be valuable in clinical practice for screening and monitoring the progression of HS.<\/jats:p>","DOI":"10.1111\/1346-8138.17661","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:25:04Z","timestamp":1738920304000},"page":"583-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Systematic review and meta\u2010analysis of peripheral blood inflammatory markers in hidradenitis Suppurativa"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2981-2630","authenticated-orcid":false,"given":"Yan\u2010Han","family":"Li","sequence":"first","affiliation":[{"name":"Division of General Practice, Department of Medical Education Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0425-1338","authenticated-orcid":false,"given":"Shu\u2010Han","family":"Chuang","sequence":"additional","affiliation":[{"name":"Division of General Practice, Department of Medical Education Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ju","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Changhua Christian Hospital  Changhua Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Treasure Island (FL): StatPearls publishing copyright \u00a9 2024","author":"Ballard K","year":"2024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0149-1"},{"key":"e_1_2_8_4_1","volume-title":"Roenigk & Roenigk's dermatologic surgery: principles and practice","author":"Roenigk RK","year":"1996"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02624.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00915.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10254.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0457-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.11.018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.07.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15458"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.08.031"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/ddg.12067","article-title":"Depression is a frequent co\u2010morbidity in patients with acne inversa. 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