{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:48:19Z","timestamp":1747201699606,"version":"3.40.3"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the COVID\u201019 pandemic, the daily life of many patients with dermatological immune\u2010mediated inflammatory diseases (DIMIDs), such as atopic dermatitis (AD), psoriasis, and vitiligo, was impacted by social restrictions caused by (fear of) morbidity, mortality associated with COVID\u201019, and vaccine hesitancy. This prospective observational, multicenter, multidisciplinary cohort study explored the impact of COVID\u201019 disease and vaccination on DIMIDs, specifically AD, psoriasis, and vitiligo. Data from patients with DIMIDs were collected as part of the Target2B! study (between February 2021 and October 2022). We analyzed the differences in baseline characteristics, risk of developing COVID\u201019, proportion of DIMIDs in patients reaching seroconversion upon vaccination per DIMID, and self\u2010reported increase in DIMID activity by multivariable logistic regression and sensitivity analyses. A total of 424 patients with DIMID were included. COVID\u201019 disease commonly occurred in patients with vitiligo (51.1%), AD (42.0%), and psoriasis (34.3%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.038). COVID\u201019 was not associated with the use of immunosuppressive therapy. Three patients (two with AD and one with vitiligo) were hospitalized due to COVID\u201019. Nearly all patients with DIMIDs exhibited effective seroconversion after regular vaccination regimens (vitiligo 100%, psoriasis 97.9%, AD 96.5%). Increased DIMID activity after COVID\u201019 (6.6%) or severe acute respiratory syndrome\u2013related coronavirus (SARS\u2010CoV\u20102) vaccination (12.26%) was reported in a minority of patients, with baseline progressive disease (disease activity 3\u2009months preceding baseline survey) being the only associated risk factor (COVID\u201019: odds ratio [OR], 4.27 [<jats:italic>p<\/jats:italic>\u2009=\u20090.02]; vaccination OR, 3.45 [<jats:italic>p<\/jats:italic>\u2009=\u20090.002]). In conclusion, no alarming signs were shown in this study regarding (severe) COVID\u201019 in patients with AD, psoriasis, or vitiligo. Vaccination against COVID\u201019 is advised in patients with DIMIDs. Moreover, patients with DIMIDs can safely continue their immunosuppressant therapy, since this does not increase the risk of COVID\u201019, while vaccination\u2010induced humoral responses are adequate. In only a minority of patients, increased DIMID activity after COVID\u201019 or SARS\u2010CoV\u20102 vaccination occurred.<\/jats:p>","DOI":"10.1111\/1346-8138.17664","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T13:05:03Z","timestamp":1739538303000},"page":"624-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of COVID\u201019 disease and vaccination on dermatological immune\u2010mediated inflammatory diseases atopic dermatitis, psoriasis, and vitiligo: a Target2B! substudy"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-0492","authenticated-orcid":false,"given":"Nicoline F.","family":"van Buchem\u2010Post","sequence":"first","affiliation":[{"name":"Department of Dermatology Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Institute for Immunology &amp; Infectious Diseases  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter","family":"Ouwerkerk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Institute for Immunology &amp; Infectious Diseases  Amsterdam Netherlands"},{"name":"National Heart Centre Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen W.","family":"Stalman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam Neuroscience Amsterdam UMC  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koos P. 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