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We evaluated the 52\u2010week effectiveness of deucravacitinib in patients with psoriasis, stratified by a history of apremilast or biologic usage. This prospective, single\u2010center study included 110 patients with moderate\u2010to\u2010severe psoriasis who received daily deucravacitinib (6\u2009mg). Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores during the treatment were analyzed in subgroups stratified by a history of apremilast or biologic usage. Deucravacitinib decreased PASI and DLQI scores for 52\u2009weeks in psoriasis patients, both with and without prior apremilast or biologic usage. The percent reductions from baseline PASI or DLQI at week 52 were similar in apremilast\u2010experienced patients (92% or 77.9%) and apremilast\u2010naive patients (88.3% or 81.6%), respectively. The achievement rates of PASI 100 or absolute PASI \u22641 at week 52 in apremilast\u2010experienced patients (30.8% or 61.5%) were slightly higher than those in apremilast\u2010naive patients (20.5% or 46.2%). The percent reductions from baseline PASI or DLQI at week 52 in biologic\u2010naive patients (91.6 or 82.8%) were slightly higher than those in biologic\u2010experienced patients (57.6% or 63.6%), respectively. The achievement rates of PASI 75, 100 or absolute PASI \u22641 at week 52 in biologic\u2010naive patients (84.4%, 24.4%, or 53.3%) were slightly higher than those in biologic\u2010experienced patients (57.1%, 14.3%, or 28.6%), respectively. Deucravacitinib generated sustained 52\u2010week effectiveness in diverse patient subgroups, supporting its role as a universal treatment for psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.17665","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:24:46Z","timestamp":1738920286000},"page":"634-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term real\u2010world effectiveness of deucravacitinib in psoriasis: A 52\u2010week prospective study stratified by prior apremilast or biologic therapy"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4183-9596","authenticated-orcid":false,"given":"Teppei","family":"Hagino","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai 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