{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:51:53Z","timestamp":1784206313870,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Juvenile\u2010onset morphea can severely impact activities of daily living by causing functional disability. This study was performed to clarify the epidemiological and clinical characteristics of juvenile\u2010onset morphea in Japan. We conducted a nationwide, two\u2010part postal survey. The first survey aimed to estimate the number of patients with juvenile\u2010onset morphea, while the second survey aimed to elucidate the epidemiological and clinical characteristics of juvenile\u2010onset morphea. This study included patients of all ages with juvenile\u2010onset morphea whose age at disease onset was &lt;18\u2009years and who visited a medical institution from 1 January, 2016 to 31 December, 2020. The first survey identified 371 patients with juvenile\u2010onset morphea. The second survey collected detailed clinical information for 315 patients with juvenile\u2010onset morphea. We estimated that the number of patients diagnosed with juvenile\u2010onset morphea from 2016 to 2020 was 591 (95% confidence interval 479\u2013702) among children aged &lt;18\u2009years. The estimated annual incidence rate of juvenile\u2010onset morphea ranged from 2.11 to 2.87 per 1\u2009000\u2009000 children aged &lt;18\u2009years from 2016 to 2019. The mean age at onset was 7.7\u2009years. Regarding subtypes, linear morphea was the most common, followed by circumscribed morphea. Complications and treatments varied widely by subtype, with local treatment primarily used for circumscribed morphea. By contrast, patients with linear morphea, generalized morphea, pansclerotic morphea, and mixed morphea had severe complications affecting daily life, and they received systemic immunosuppressive therapy more frequently. The prognosis of juvenile\u2010onset morphea was generally favorable. The results of this study are expected to help in the development of appropriate diagnostic and therapeutic approaches for juvenile\u2010onset morphea.<\/jats:p>","DOI":"10.1111\/1346-8138.17684","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:40:23Z","timestamp":1741714823000},"page":"860-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nationwide epidemiological and clinical survey of juvenile\u2010onset morphea in Japan"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-7770","authenticated-orcid":false,"given":"Yasuhito","family":"Hamaguchi","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-5691","authenticated-orcid":false,"given":"Ikuko","family":"Ueda\u2010Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9162-336X","authenticated-orcid":false,"given":"Utako","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Miyamae","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Institute of Rheumatology, Tokyo Women's Medical University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Molecular\u2010Targeting Prevention Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Ae","sequence":"additional","affiliation":[{"name":"Division of Public Health, Center for Community Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Public Health, Center for Community Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Ministry of Health, Labour and Welfare's Localized Scleroderma Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390624"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.02.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei251"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330508"},{"key":"e_1_2_9_6_1","unstructured":"KawamuraT.[A manual of a nationwide epidemiological survey for estimating the number of patients and assessing clinico\u2010epidemiological characteristics of patients with intractable diseases (2nd edition)] [in Japanese]. 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