{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:37:18Z","timestamp":1777563438764,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Yusho, a dioxin poisoning incident in Japan, has resulted in patients experiencing persistent symptoms, including sensory disturbances, decades after the initial exposure. This study investigated the potential involvement of the descending pain inhibitory system in Yusho patients. Serum serotonin, dopamine, and norepinephrine levels were measured in 29 Yusho patients and 29 age\u2010matched healthy controls. No significant differences in these neurotransmitters were observed between the two groups. However, weak correlations were found between polychlorinated biphenyl levels and dopamine (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.4310,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0315) in Yusho patients. This study provides new insights into the pathophysiology of cutaneous sensory disorders and highlights the need for further research to clarify the long\u2010term effects of dioxin exposure on Yusho patients.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17689","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:30:19Z","timestamp":1741685419000},"page":"934-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Blood levels of neurotransmitters in Yusho patients: An approach via the descending pain inhibitory pathway for persistent sensory disturbance"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4215-680X","authenticated-orcid":false,"given":"Miwa","family":"Ashida","sequence":"first","affiliation":[{"name":"Department of Dermatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"},{"name":"Research and Clinical Center for Yusho and Dioxin Kyushu University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Murayama","sequence":"additional","affiliation":[{"name":"Sasebo City General Hospital  Sasebo\u2010shi Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kamio","sequence":"additional","affiliation":[{"name":"Honda Dermatology Allergy Clinic  Omura\u2010shi Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Yozaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8444-6792","authenticated-orcid":false,"given":"Yutaka","family":"Kuwatsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Research and Clinical Center for Yusho and Dioxin Kyushu University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-1377","authenticated-orcid":false,"given":"Hiroyuki","family":"Murota","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7201119"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2013.835890"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109415"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-015-0059-y"},{"key":"e_1_2_8_6_1","unstructured":"Kyushu University Graduate School of Medical Sciences Department of Dermatology. 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