{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:38:23Z","timestamp":1780569503577,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with peach allergy who experience severe symptoms, including anaphylaxis, reportedly have a higher positivity for peach gibberellin\u2010regulated protein (GRP)\u2010specific immunoglobulin (Ig) E than those with only oral symptoms. However, a study in Italy investigating apple allergy (another Rosaceae fruit) found no clear association between apple GRP\u2010specific IgE levels and clinical disease types. This study aimed to evaluate the clinical utility of GRP\u2010specific IgE measurement in Japanese patients with apple allergy. We collected sera from apple\u2010allergic patients in Japan and measured their IgE levels specific to apple GRP. Apple\u2010allergic patients (14 with oral reactions and 14 with systemic reactions) and seven non\u2010allergic controls were examined. The specific IgE levels against apple, Mal d 1, Mal d 4, Japanese cedar, Japanese alder, Japanese white birch, Bet v 1, and Bet v 2 were also determined using 3gAllergy\u2122. Positive results for apple\u2010GRP\u2010specific IgE by enzyme\u2010linked immunosorbent assay were obtained in one patient with oral reactions and in seven cases of systemic reactions. Exercise as a cofactor was involved in cases with high apple GRP\u2010specific IgE. GRP expression was considerably lower in apples than in peaches, as detected by reverse transcription\u2010quantitative polymerase chain reaction testing. Thus, GRP\u2010specific IgE may be an important marker for diagnosing systemic reactions triggered by exercise in fruits with low GRP expression, such as apples.<\/jats:p>","DOI":"10.1111\/1346-8138.17691","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:23:51Z","timestamp":1741760631000},"page":"888-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Usefulness of gibberellin\u2010regulated protein specific\n                    <scp>IgE<\/scp>\n                    measurement in patients with systemic symptoms of apple allergy with exercise"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-080X","authenticated-orcid":false,"given":"Yuji","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fujita Health University, Bantane Hospital  Aichi 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