{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:30:20Z","timestamp":1789576220188,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by erythema, pustules, and desquamation of the palms and soles. PPP epidemiological data are scarce. Understanding disease characteristic is essential for effective management and to reduce burden. The objective of the study was to describe disease characteristics of PPP in Korea, including demographics, disease burden, and current clinical practice. This was a cross\u2010sectional, multicenter, noninterventional study conducted among 20 sites in Korea. Patients (aged \u226519\u2009years) with a confirmed PPP diagnosis were examined and interviewed, collecting clinical and patient\u2010reported outcomes in 1\u2009day. A total of 379 patients with PPP (mean age, 51.4\u2009years; 39.3% male) were enrolled. The mean age at diagnosis was 47.9\u2009years, and the mean duration of PPP was 3.2\u2009years. Mean\u00b1standard deviation of Palmoplantar Pustulosis Area and Severity Index (PPPASI) score was 10.3\u00b19.0; 33.8% of patients scored \u226512. PPPASI score was significantly higher with younger age (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0001) and nail involvement (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002). Mean Dermatology Life Quality Index (DLQI) score was 12.0, and mean EuroQoL 5\u2010Dimension Health Questionnaire (EQ\u20105D) score was 62.4\u2009\u00b1\u200919. Patients with PPPASI \u226512 had significantly higher DLQI (14.1\u2009\u00b1\u20097.3 vs 10.9\u2009\u00b1\u20097.6;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and lower EQ\u20105D (57.9\u2009\u00b1\u200918.1 vs 64.7\u2009\u00b1\u200919.2;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) scores. The most common treatments in patients with PPPASI &lt;12 were topicals (50.6%), conventional therapies (34.7%), and retinoids (32.7%); the most common treatments with PPPASI \u226512 were conventional therapies (37.5%), topicals (34.4%), and retinoids (29.7%). Conventional therapy users were \u201cmore satisfied\u201d than nonusers (49.6% vs 39.0%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05), with a numerical difference observed for biologics (41.8% vs 63.1%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.07). PPP is a debilitating disease that significantly diminishes overall quality of life. Despite most patients receiving treatment, PPP burden persists. Developing treatment guidelines and identifying more targeted and effective treatments would help alleviate symptoms, reduce severity, and improve overall quality of life.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17702","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T11:04:28Z","timestamp":1743591868000},"page":"802-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Disease features, treatments, and burden of palmoplantar pustulosis in Korea: The\n                    <scp>EPPPIK<\/scp>\n                    study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-7672","authenticated-orcid":false,"given":"Seong Jin","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0054-8570","authenticated-orcid":false,"given":"Byung Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pusan National University School of Medicine  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-2400","authenticated-orcid":false,"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHA University Bundang Medical Center  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-8180","authenticated-orcid":false,"given":"Jong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gangnam Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hallym University Kangnam Sacred Heart Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Wook","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital  Ansan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-9978","authenticated-orcid":false,"given":"Jiyoung","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeoun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chungbuk National University Hospital  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Heon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyung Hee University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngdoe","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Affairs Janssen Korea Ltd.  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