{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:35:34Z","timestamp":1774272934607,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In this study, we investigated whether circulating\n                    <jats:italic>S100A7<\/jats:italic>\n                    and\n                    <jats:italic>S100A15<\/jats:italic>\n                    DNA copies in cell\u2010free DNA (cfDNA) are elevated in patients with psoriasis and atopic dermatitis (AD) and their levels are correlated with clinical findings. Serum cfDNA was obtained from 124 psoriasis patients and 45 AD patients. Circulating\n                    <jats:italic>S100A7<\/jats:italic>\n                    and\n                    <jats:italic>S100A15<\/jats:italic>\n                    DNA copies in psoriasis and AD patients were significantly higher than in healthy controls. Although circulating\n                    <jats:italic>S100A7<\/jats:italic>\n                    and\n                    <jats:italic>S100A15<\/jats:italic>\n                    DNA copies showed a significant positive correlation with the Psoriasis Severity and Area Index (PASI) scores in patients with severe psoriasis (PASI\u2009\u2265\u200910), in AD patients there was no significant correlation between their levels and disease severity. Furthermore, in psoriasis patients, circulating\n                    <jats:italic>S100A15<\/jats:italic>\n                    DNA copies were significantly decreased in patients after treatment compared with patients before treatment.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17727","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T10:49:45Z","timestamp":1743590985000},"page":"1098-1102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum circulating\n                    <i>S100A7<\/i>\n                    and\n                    <i>S100A15<\/i>\n                    DNA copies are elevated in patients with psoriasis and atopic dermatitis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7113-9539","authenticated-orcid":false,"given":"Shuji","family":"Yamamura","sequence":"first","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tselmeg Mijiddorj","family":"Myangat","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-9316","authenticated-orcid":false,"given":"Soichiro","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8900-3520","authenticated-orcid":false,"given":"Shuichi","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-809X","authenticated-orcid":false,"given":"Kayo","family":"Kashiwada\u2010Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3080-1621","authenticated-orcid":false,"given":"Ikko","family":"Kajihara","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunari","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto 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