{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:06:23Z","timestamp":1791522383187,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Psoriasis is associated with comorbidities like metabolic syndrome and nonalcoholic fatty liver disease, increasing the risk of liver fibrosis. This study evaluated the long\u2010term effects of guselkumab on liver fibrosis in 154 psoriasis patients using the Fibrosis\u20104 (FIB\u20104) index, a noninvasive marker of fibrosis, over 3\u2009years. Patients were stratified by baseline FIB\u20104 (\u2265\u20091.3 or &lt;\u20091.3) and age (35\u201365\u2009years). Mean FIB\u20104 values remained stable across all subgroups, with no significant changes observed. High\u2010risk patients (FIB\u20104\u2009\u2265\u20091.3) showed minor, nonsignificant fluctuations, while low\u2010risk patients (FIB\u20104\u2009&lt;\u20091.3) exhibited a mild, age\u2010related upward trend. Disease duration emerged as a key factor influencing FIB\u20104, highlighting the importance of early treatment. These findings suggest guselkumab does not contribute to liver fibrosis progression in psoriasis patients. Further research with advanced methods like imaging or biopsy is needed to confirm the long\u2010term hepatic safety of IL\u201023 inhibitors like guselkumab.<\/jats:p>","DOI":"10.1111\/1346-8138.17752","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T08:29:18Z","timestamp":1744792158000},"page":"1113-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Guselkumab on the\n                    <scp>FIB<\/scp>\n                    \u20104 Index in Psoriasis Patients (\n                    <scp>EGIPT<\/scp>\n                    ): A Three\u2010Year Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3763-6922","authenticated-orcid":false,"given":"Edoardo","family":"Mortato","sequence":"first","affiliation":[{"name":"Department of Systems Medicine University of Rome Tor Vergata  Rome 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