{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:53:59Z","timestamp":1785333239825,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Biologic therapies targeting interleukin (IL)\u201017 and IL\u201023 have transformed psoriasis treatment, yet real\u2010world evidence on the impact of age on treatment responses and drug survival is limited. This study aims to compare early (12\/16\u2009weeks), mid term (24\u2009weeks) and long term (52\u2009weeks) Psoriasis Area and Severity Index (PASI) responses and drug survival in psoriasis patients aged &lt;\u200965 versus \u2265\u200965\u2009years receiving IL\u201017 or IL\u201023 inhibitors. In this retrospective study, 121 patients with moderate\u2010to\u2010severe plaque psoriasis treated with secukinumab, ixekizumab, guselkumab, or risankizumab were analyzed. Patients were stratified into two age groups (&lt;\u200965, <jats:italic>n<\/jats:italic> =\u200978; \u2265\u200965, <jats:italic>n<\/jats:italic> =\u200943). PASI75, PASI90, and PASI &lt;\u20092 outcomes were assessed at 12\/16, 24, and 52\u2009weeks. Drug survival was evaluated via Kaplan\u2013Meier analysis (censoring at 24 months) and Cox regression was used to identify predictors of discontinuation. At 12\/16\u2009weeks, the &lt;\u200965 group achieved significantly higher PASI75 (90.5% vs. 65.1%, <jats:italic>p<\/jats:italic> =\u20090.010), PASI90 (75.7% vs. 32.6%, <jats:italic>p<\/jats:italic> =\u20090.030) and PASI &lt;\u20092 (55.8% vs. 79.7%, <jats:italic>p =<\/jats:italic> 0.006) responses than the \u2265\u200965 group. At 52\u2009weeks, PASI75, PASI90, and PASI &lt;\u20092 rates were similar between groups (86.3% vs. 97.5%, <jats:italic>p<\/jats:italic> =\u20090.055; 78% vs. 90%, <jats:italic>p<\/jats:italic> =\u20090.112; 85.1% vs. 92.5%, <jats:italic>p<\/jats:italic> =\u20090.253). There were no significant differences between IL\u201017 and IL\u201023 inhibitors within any age group. Overall drug survival at 24 months was high (79.6% for &lt;\u200965 and 90.3% for \u2265\u200965, log\u2010rank <jats:italic>p<\/jats:italic> =\u20090.407), with no difference between biologic classes (mean survival: 21.8 vs. 22.4 months, <jats:italic>p<\/jats:italic> =\u20090.520). In Cox regression, female sex (HR 0.23, <jats:italic>p<\/jats:italic> =\u20090.005) and higher baseline PASI (HR 1.093 per point, <jats:italic>p<\/jats:italic> =\u20090.013) predicted discontinuation, whereas age, biologic class, BMI, and prior biologic use were not significant. Despite a delayed initial response, older patients achieve long\u2010term PASI outcomes comparable to younger patients when treated with IL\u201017 and IL\u201023 inhibitors. Drug survival is similarly excellent across age groups and biologic classes. These findings support the successful use of modern biologics in elderly psoriasis patients.<\/jats:p>","DOI":"10.1111\/1346-8138.17755","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T07:49:11Z","timestamp":1745653751000},"page":"1166-1174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and Safety of <scp>IL<\/scp>\u201017 and <scp>IL<\/scp>\u201023 Inhibitors in Elderly Patients With Plaque Psoriasis: A Real\u2010World Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-9549","authenticated-orcid":false,"given":"Fatmanur","family":"Hac\u0131necipo\u011flu","sequence":"first","affiliation":[{"name":"Department of Dermatology Ankara Etlik City Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0032-5572","authenticated-orcid":false,"given":"G\u00f6k\u00e7en","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara Etlik City Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-8635","authenticated-orcid":false,"given":"Selda Pelin","family":"Kartal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara Etlik City Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12850"},{"issue":"8","key":"e_1_2_8_5_1","first-page":"846","article-title":"Biologic and Conventional Systemic Therapies Show Similar Safety and Efficacy in Elderly and Adult Patients With Moderate to Severe Psoriasis","volume":"14","author":"Garber C.","year":"2015","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12237215"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19355"},{"key":"e_1_2_8_8_1","volume-title":"Proposed Working Definition of an Older Person in Africa for the MDS Project","author":"World Health Organization","year":"2016"},{"key":"e_1_2_8_9_1","first-page":"2019","volume-title":"World Population Ageing 2019","author":"United Nations, Department of Economic and Social Affairs, Population Division","year":"2019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.1677"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-022-00961-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20143"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.03.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2133531"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1809623"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00722-y"},{"issue":"12","key":"e_1_2_8_17_1","article-title":"Use of Biological Treatments in Elderly Patients With Skin Psoriasis in the Real World","volume":"11","author":"Osuna C. 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