{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:33:24Z","timestamp":1789133604911,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Clinical trials have demonstrated the efficacy and safety of guselkumab in patients with moderate\u2010to\u2010severe plaque psoriasis. Real\u2010world evidence for guselkumab in Korea is needed to establish drug safety and effectiveness under real\u2010world practice in this population. This study assessed the effectiveness, safety, and drug survival of guselkumab in Korean patients with moderate\u2010to\u2010severe plaque psoriasis in a real\u2010world clinical setting. In this prospective, non\u2010interventional observational study conducted at 44 clinical centers in South Korea, adult patients with moderate\u2010to\u2010severe plaque psoriasis who would receive guselkumab per the product label were enrolled. Disease assessment was performed at visits 1 (baseline, week 0), 2 (approximately week 4), and 3\u20137 (approximately every 8\u2009weeks after week 4, weeks 12\u201344). Between February 25, 2019 and March 25, 2022, 707 patients were enrolled and 562 (79.5%) had completed the 56\u2010week observation period. The proportions of patients with an absolute Psoriasis Area and Severity Index (PASI) score of \u2264\u20093, \u2264\u20092, or \u2264\u20091 reached maximums of 96.0%, 86.7%, and 59.0%, respectively, at visit 7. A significantly greater proportion of biologic\u2010na\u00efve (vs. biologic\u2010experienced) patients achieved absolute PASI \u2264\u20093 by visits 5\u20137 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001 at visit 7) and absolute PASI \u2264\u20092 by visits 6\u20137 (<jats:italic>p<\/jats:italic>\u2009=\u20090.0014 at visit 7). Dermatology Life Quality Index (DLQI) scores decreased over time, with 64.1% of patients achieving DLQI 0\/1 by visit 7; results were similar regardless of prior biologic therapy. The estimated drug\u2010survival rate at 1\u2009year was 92.7%. Adverse events (AEs) occurred in 22.5% of patients, with an incidence rate of 42.1 per 100 patient years (PY); 14 serious AEs occurred in 13 (1.8%) patients, with an incidence rate (95% confidence interval) of 2.4 (1.2\u20133.7) per 100 PY. Guselkumab administered under approved label conditions was effective and well\u2010tolerated in Korean patients with moderate\u2010to\u2010severe plaque psoriasis in a real\u2010world clinical setting.<\/jats:p>","DOI":"10.1111\/1346-8138.17757","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T12:16:43Z","timestamp":1745842603000},"page":"1125-1137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and Safety of Guselkumab in Patients With Moderate\u2010to\u2010Severe Plaque Psoriasis in Real\u2010World Practice in Korea: A Prospective, Multicenter, Observational, Postmarketing Surveillance Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Bong Seok","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Dermatology Chosun University College of Medicine  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-3449","authenticated-orcid":false,"given":"Miri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Kyu","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dongguk University College of Medicine  Gyeongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Bok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Uijeongbu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-3530","authenticated-orcid":false,"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeoun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Chungbuk National University  Cheongju Chungbuk Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kangdong Sacred Heart Hospital, Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Wook","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital  Ansan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hallym University Sacred Heart Hospital, Hallym University College of Medicine  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2598-7600","authenticated-orcid":false,"given":"Jihye","family":"An","sequence":"additional","affiliation":[{"name":"Medical Affairs, Janssen Korea Ltd.  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