{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:14:20Z","timestamp":1772993660235,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This cross\u2010sectional pilot study investigated the clinical characteristics of anti\u2010centromere antibody (ACA)\u2013positive patients with below\u2010the\u2010knee arterial disease. Sixteen ACA\u2010positive patients (mean age 69\u2009\u00b1\u200910\u2009years; 94% women) underwent contrast\u2010enhanced computed tomography evaluation, with arterial damage scored using the Global Limb Anatomic Staging System. Lower extremity arterial disease (LEAD) was defined as a below\u2010the\u2010knee arterial score \u2265\u20091 or &gt;\u200950% stenosis in above\u2010the\u2010knee lesions. Eight patients were categorized into the LEAD group (below\u2010the\u2010knee arterial damage score 12\u2009\u00b1\u20096). The LEAD group showed significantly higher serum IgG1 levels (1029\u2009\u00b1\u2009484 vs. 531\u2009\u00b1\u200972\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and a higher prevalence of diastolic dysfunction (62% vs. 0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026) compared to the non\u2010LEAD group. Patients with diastolic dysfunction had significantly higher serum IgG1 levels than those without (1190\u2009\u00b1\u2009559 vs. 593\u2009\u00b1\u2009139\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). These findings suggest associations between elevated serum IgG1 levels, below\u2010the\u2010knee arterial disease, and left ventricular diastolic dysfunction in ACA\u2010positive patients.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17783","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T06:09:51Z","timestamp":1747375791000},"page":"1070-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Serum Immunoglobulin\n                    <scp>G1<\/scp>\n                    Levels and Left Ventricular Diastolic Dysfunction in Anti\u2010Centromere Antibody\u2013Positive Patients With Lower Extremity Arterial Disease: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Tatsuya","family":"Shiraki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Osaka Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-9272","authenticated-orcid":false,"given":"Hidetaka","family":"Kioka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Osaka Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-5691","authenticated-orcid":false,"given":"Ikuko","family":"Ueda\u2010Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Osaka Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The University of Osaka Graduate School of Medicine  Suita Japan"},{"name":"Department of Clinical Laboratory The University of Osaka Hospital  Suita 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Enchi","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Medical Technology The University of Osaka Hospital  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The University of Osaka Hospital  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Takahari","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Osaka Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Osaka Graduate School of Medicine  Suita 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