{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:59:08Z","timestamp":1788994748071,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin disease driven by immune dysregulation. This study explores the role of B cells, particularly cytokine\u2010producing subsets, in psoriasis pathogenesis. Although T cells, particularly Th17, have been well documented in psoriasis, recent evidence suggests that B cells contribute to the disease process. Flow cytometry analysis of 50 psoriasis patients and 20 healthy controls revealed a significant increase in IL\u20106\u2013producing effector B cells (Beffs) and a decrease in IL\u201010\u2013producing regulatory B cells (Bregs) in psoriasis patients. As IL\u20106 is pro\u2010inflammatory and IL\u201010 is anti\u2010inflammatory, this imbalance likely exacerbates inflammation in psoriasis. The study also examined the effects of guselkumab, an IL\u201023 inhibitor, on cytokine\u2010producing B cells. The frequency of IL\u20106\u2013producing Beffs in the blood was significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) elevated in patients with psoriasis compared with that in healthy controls. In contrast, the frequency of IL\u201010\u2013producing Bregs in the blood was significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) decreased in patients with psoriasis compared with that in healthy controls. In 10 biologic\u2010na\u00efve psoriasis patients, guselkumab significantly reduced IL\u20106\u2013producing Beffs 4\u2009weeks posttreatment, corresponding with a marked decrease in the Psoriasis Area and Severity Index (PASI). However, IL\u201010\u2013producing Bregs showed no significant change over this period, suggesting that regulatory B cell recovery may require a longer timeframe or additional stimuli. These findings highlight the potential of B cells as biomarkers for disease activity and therapeutic response in psoriasis. The observed cytokine imbalance suggests that targeting B cell\u2010mediated inflammation could be a novel therapeutic avenue. Further research is needed to assess long\u2010term Breg dynamics and their role in maintaining immune homeostasis in psoriasis. This study reinforces the importance of both effector and regulatory B cells in psoriasis and suggests that monitoring their balance may improve disease characterization and treatment strategies.<\/jats:p>","DOI":"10.1111\/1346-8138.17804","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T06:26:14Z","timestamp":1750400774000},"page":"1297-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Disrupted B\u2010Cell Cytokine Homeostasis in Psoriasis: The Impact of Elevated <scp>IL<\/scp>\u20106 and Impaired <scp>IL<\/scp>\u201010 Production"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3824-323X","authenticated-orcid":false,"given":"Tasuku","family":"Kitano","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa 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