{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:00:55Z","timestamp":1791856855173,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Flat warts are typically caused by human papillomavirus (HPV) type 3 or 10, while HPV 94 is rarely detected. The warts on a 76\u2010year\u2010old Japanese male with rheumatoid arthritis (RA) appeared after 8\u2009months of tofacitinib treatment but disappeared upon switching to filgotinib. However, the warts reappeared when tofacitinib was resumed. Histopathological and DNA sequencing confirmed HPV 94. While Janus kinase (JAK) inhibitors are known to increase viral reactivation risks, including herpes zoster, this case highlights a possible link between tofacitinib and HPV 94\u2010related flat warts. Tofacitinib may suppress IL\u201015 signaling, weakening antiviral immunity and promoting HPV reactivation. Although HPV\u2010specific immunity in RA\u2010 and tofacitinib\u2010treated patients remains unclear, this case provides new insights into JAK inhibitor\u2013related viral reactivation, particularly for HPV 94\u2013associated flat warts.<\/jats:p>","DOI":"10.1111\/1346-8138.17814","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:00:23Z","timestamp":1749614423000},"page":"1317-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Human Papilloma Virus Type 94\u2013Associated Flat Warts Developing Repeatedly During Tofacitinib Treatment: A Case Report and Review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9873-3367","authenticated-orcid":false,"given":"Nobuhiro","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokai University School of Medicine  Kanagawa 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