{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:30:30Z","timestamp":1782178230176,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016730","name":"Torii Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This open\u2010label, single\u2010arm, multicenter clinical study evaluated the treatment satisfaction, efficacy, and safety of 0.5% delgocitinib ointment twice daily for 12\u2009weeks, applied to face\/neck lesions caused by \u2265\u20093\u2009months use of topical steroids or tacrolimus ointment in patients with atopic dermatitis (AD). The primary endpoint was change in treatment satisfaction (Treatment Satisfaction Questionnaire for Medication\u20109 [TSQM\u20109]). Secondary endpoints included changes in modified Eczema Area and Severity Index (mEASI) and EASI scores, the numerical rating scale (NRS) for pruritus, the severity of side effects, skin condition at target lesions, disease control (Atopic Dermatitis Control Tool [ADCT]), and preference for delgocitinib ointment (Patient Preference Questionnaire [PPQ]). Overall, 38 patients (mean age 40\u2009years) with a duration of AD of 30.7\u2009years were included in the study. Scores of TSQM\u20109 for global satisfaction (Week 0: 58.8\u2009\u00b1\u200914.7; Week 4: 68.5\u2009\u00b1\u200916.6; Week 12: 73.2\u2009\u00b1\u200916.0), effectiveness (57.0\u2009\u00b1\u200914.1; 67.0\u2009\u00b1\u200912.6; 70.9\u2009\u00b1\u200913.4), and convenience (64.9\u2009\u00b1\u200915.0; 73.6\u2009\u00b1\u200912.7; 76.1\u2009\u00b1\u200913.6) (all cases <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), mEASI (Week 0: 1.31; Week 12: 0.68, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and NRS (4.53; 2.71, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) scores, and ADCT (8.3; 5.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were improved significantly. Compared with that at Week 0, the incidence of \u2265\u2009mild skin atrophy, telangiectasia, and skin irritation decreased. The PPQ showed that approximately 80% of patients rated all queries as \u201cstrongly agree\u201d or \u201cagree.\u201d In addition, skin conditions were significantly improved for all items (dryness, feel, firmness\/elasticity, and appearance) at 1\u20132\u2009weeks and 12\u2009weeks (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The present results demonstrate that delgocitinib ointment might be an effective option for switching treatment for face\/neck AD in patients with skin lesions, or for those who are concerned about the development of side effects related to steroids or tacrolimus.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> Japan Registry of Clinical Trials (jRCTs031230063)<\/jats:p>","DOI":"10.1111\/1346-8138.17817","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T03:25:04Z","timestamp":1750908304000},"page":"1232-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment Satisfaction, Efficacy, and Safety of Delgocitinib Ointment for Atopic Dermatitis\u2010Induced Rash on the Face and Neck: Efficacy at Reducing Local Side Effects of Topical Steroid and Tacrolimus Ointment"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-9428","authenticated-orcid":false,"given":"Masatoshi","family":"Abe","sequence":"first","affiliation":[{"name":"Kojinkai Sapporo Skin Clinic  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-3187","authenticated-orcid":false,"given":"Atsuyuki","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Igarashi Dermatology Higashigotanda  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Torii Pharmaceutical Co., Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-8520","authenticated-orcid":false,"given":"Hiroyuki","family":"Toyama","sequence":"additional","affiliation":[{"name":"Torii Pharmaceutical Co., Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-0554","authenticated-orcid":false,"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-0355","authenticated-orcid":false,"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"2741","article-title":"Guidelines for the Management of Atopic Dermatitis 2024","volume":"134","author":"Saeki H.","year":"2024","journal-title":"Japanese Journal of Dermatology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16527"},{"key":"e_1_2_10_4_1","first-page":"1491","article-title":"Survey of the Use of Topical Drugs for Atopic Dermatitis","volume":"133","author":"Igarashi A.","year":"2023","journal-title":"Japanese Journal of Dermatology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-014-0782-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15173"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.06.014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03473.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00500-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15090"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.08.030"},{"key":"e_1_2_10_13_1","article-title":"Topical Anti\u2010Inflammatory Treatments for Eczema: Network Meta\u2010Analysis","volume":"8","author":"Lax S. 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