{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:46:05Z","timestamp":1792691165241,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Baricitinib, a Janus kinase inhibitor, demonstrated efficacy in achieving scalp hair regrowth in severe alopecia areata (AA). While short\u2010term real\u2010world data on its efficacy have been reported, long\u2010term data remain limited. This retrospective observational study spanning 104\u2009weeks analyzed clinical trajectories of 51 severe AA patients treated with baricitinib. Among them, 36 continued treatment for 104\u2009weeks, with 55.6% achieving a SALT score of \u2264\u200920 and 72.2% achieving \u2265\u200930% improvement from baseline in SALT score (SALT<jats:sub>30<\/jats:sub>). Multivariate analysis identified female sex and disease duration &lt;\u20094\u2009years as significant predictors of response. Furthermore, patients with eyebrow or eyelash regrowth at 52\u2009weeks had a higher likelihood of achieving long\u2010term scalp hair regrowth. We identified a subgroup of markedly slow responders who achieved SALT<jats:sub>30<\/jats:sub> between 52 and 104\u2009weeks, many of whom had eyebrow or eyelash regrowth at 52\u2009weeks. Baricitinib was well tolerated throughout the study period, with no serious long\u2010term adverse effects. Our findings supported baricitinib's long\u2010term efficacy and safety and suggested predictive factors for treatment responses in severe AA.<\/jats:p>","DOI":"10.1111\/1346-8138.17829","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T06:11:29Z","timestamp":1750399889000},"page":"1321-1325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010Term Real\u2010World Outcomes of Baricitinib in Severe Alopecia Areata: A 104\u2010Week Retrospective Analysis From a Single Institute"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-4339","authenticated-orcid":false,"given":"Moyuka","family":"Wada\u2010Irimada","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Miyagi 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