{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:15:59Z","timestamp":1788513359030,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A 49\u2010year\u2010old man with pemphigus vegetans (PVeg) relapsed several times due to cessation of therapy. At the age of 66, vegetative plaques developed at the left oral commissure following mechanical plucking of approximately 500 beard hairs. Treatment with prednisolone (20\u2009mg\/day) was continued but yielded no clinical improvement. Subsequently, rituximab (1000\u2009mg twice, 2\u2009weeks apart) led to a rapid decline of anti\u2010desmoglein 3 (Dsg3) autoantibody and clinical improvement. The lesion resolved after 18\u2009months, and prednisolone was tapered without recurrence. Based on the site\u2010specific recurrence and chronicity, we hypothesized that tissue\u2010resident memory T (T\n                    <jats:sub>RM<\/jats:sub>\n                    ) cells and high endothelial venules (HEV)\u2010like vessels contributed to disease persistence. Immunohistochemical analysis revealed a substantial presence of IL\u201017A\u2010producing CD69 +\n                    <jats:sup>+<\/jats:sup>\n                    CD103 +\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    cells in the dermis. In addition, PNAd+\n                    <jats:sup>+<\/jats:sup>\n                    HEV\u2010like vessels were increased, accompanied by infiltrates of B cells and plasma cells. Notably, Dsg3\u2010specific B cells were also detected, indicating that rituximab\u2010mediated B cell depletion likely contributed to lesion resolution in this case.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17854","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T08:20:13Z","timestamp":1751962813000},"page":"1452-1455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Local Relapse of Pemphigus Vegetans Detected\n                    <scp>IL<\/scp>\n                    \u2010\n                    <scp>17A<\/scp>\n                    <sup>+<\/sup>\n                    Tissue\u2010Resident Memory T Cells in Lesional Skin"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7511-4477","authenticated-orcid":false,"given":"Maho","family":"Matsuo","sequence":"first","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Asahina","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"},{"name":"Center for one Medicine Innovative Translational Research (COMIT) Institute for Advanced Study, Gifu University  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Tawada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4158-8401","authenticated-orcid":false,"given":"Kayoko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-2735","authenticated-orcid":false,"given":"Hiroaki","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.26"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30070-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13515"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900767"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.618897"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tria.2024.100379"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-021-09792-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI166357"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.01.030"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.07.717"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502641"}],"container-title":["The 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Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.17854","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:41:41Z","timestamp":1788511301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/1346-8138.17854"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17854","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]},"assertion":[{"value":"2025-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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