{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:45:58Z","timestamp":1790207158470,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24lk0201138h0004"],"award-info":[{"award-number":["24lk0201138h0004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, life\u2010threatening cutaneous adverse reactions that have limited treatment options when systemic corticosteroids prove ineffective. To assess the efficacy and safety of etanercept in patients with SJS\/TEN who failed to respond adequately to systemic corticosteroid therapy. In this multicenter, open\u2010label, single\u2010arm study conducted in Japan, patients with SJS or TEN unresponsive to \u2265\u20092\u2009days of systemic corticosteroids (prednisolone\u2010equivalent \u2265\u200920\u2009mg\/day) were enrolled. Etanercept 50\u2009mg was administered subcutaneously on Day 1, with additional doses on Days 8 and 15 if re\u2010epithelialization remained incomplete. The primary outcome was time to complete re\u2010epithelialization. Secondary endpoints included time to cessation of skin progression, hospitalization duration, disease severity scores, ocular complications, and safety outcomes. Eight Japanese patients (mean age: 63.4\u2009years; SJS: 5, TEN: 3) were treated. The median time to complete re\u2010epithelialization was 10\u2009days (95% Confidence interval: 6.0\u201320.0). All patients achieved re\u2010epithelialization within 29\u2009days. The mean time to cessation of skin progression was 4.0\u2009days, and the mean hospitalization duration was 19.3\u2009days. No deaths occurred. Adverse events were reported in six patients (75%), including two serious infections (cytomegalovirus and cryptococcosis). However, none were judged related to etanercept. No treatment discontinuations occurred. Etanercept could be an effective and safe treatment option for patients with SJS\/TEN unresponsive to systemic corticosteroids. These findings warrant validation in larger, controlled studies.<\/jats:p>","DOI":"10.1111\/1346-8138.17860","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T12:25:51Z","timestamp":1752495951000},"page":"1536-1544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and Safety of Etanercept in Japanese Patients With Stevens\u2013Johnson Syndrome and Toxic Epidermal Necrolysis Unresponsive to Systemic Steroid Therapy: A Multicenter, Open\u2010Label, Single\u2010Arm Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-3442","authenticated-orcid":false,"given":"Haruna","family":"Kimura","sequence":"first","affiliation":[{"name":"Division of Dermatology Niigata University Graduate School of Medical and Dental Sciences  Niigata 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