{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:01:47Z","timestamp":1764169307379,"version":"3.46.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n The prognostic utility of 18F\u2010fluorodeoxyglucose positron emission tomography (FDG\u2010PET) in adult T\u2010cell leukemia\/lymphoma (ATLL) remains unclear, particularly in patients with indolent subtypes and cutaneous involvement. This study aimed to evaluate the usefulness of FDG\u2010PET in predicting clinical outcomes in patients with indolent ATLL presenting with skin lesions. We retrospectively reviewed indolent ATLL with cutaneous involvement who underwent\n 18<\/jats:sup>\n F\u2010fluorodeoxyglucose positron emission tomography at our institute for initial disease staging between April 2007 and March 2022. The data obtained were compared with the findings of cutaneous involvement in ATLL. The effect of maximum standardized uptake value on progression\u2010free survival was analyzed using the Kaplan\u2013Meier method. Patients were divided into groups based on whether their maximum standardized uptake value was above or below the overall mean maximum standardized uptake value (2.18), and progression\u2010free survival was compared between the groups. Forty\u2010three patients with indolent ATLL were included. We divided the cutaneous involvement of ATLL into six subtypes according to a previously reported classification of eruption types: patch, plaque, multipapular, nodulotumoral, erythrodermic, and purpuric. A total of 18 of 43 patients (41.9%) had\n 18<\/jats:sup>\n F\u2010fluorodeoxyglucose\u2010positive cutaneous lesions. However, 25 patients showed no\n 18<\/jats:sup>\n F\u2010fluorodeoxyglucose uptake in cutaneous lesions. There was a significant difference in the mean maximum standardized uptake value between the nodulotumoral and multipapular (\n p<\/jats:italic>\n \u2009=\u20090.036), nodulotumoral and patch (\n p<\/jats:italic>\n \u2009=\u20090.036). There was a statistically significant difference in progression\u2010free survival between the maximum standardized uptake value\u2009\u2265\u20092.18 and\u2009<\u20092.18 groups (\n p<\/jats:italic>\n \u2009=\u20090.020). These findings indicate that the maximum standardized uptake value in cutaneous lesions could determine the prognostic association of ATLL with cutaneous lesions. Careful follow\u2010up is required for patients with a higher maximum standardized uptake value for cutaneous lesions.\n <\/jats:p>","DOI":"10.1111\/1346-8138.17867","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T07:11:06Z","timestamp":1754464266000},"page":"1519-1526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maximum Standard Uptake Value of Pre\u2010Therapeutic\n \n 18<\/sup>\n F\n <\/scp>\n \u2010Fluorodeoxyglucose Positron Emission Tomography Predicts Outcomes in Indolent Adult T\u2010Cell Leukemia\/Lymphoma Patients With Cutaneous Involvement"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3555-6855","authenticated-orcid":false,"given":"Kyoko","family":"Nogami","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Faculty Miyazaki of Medicine Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4796-9711","authenticated-orcid":false,"given":"Yotaro","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Faculty Miyazaki of Medicine Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2460-8139","authenticated-orcid":false,"given":"Kosuke","family":"Mochida","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Faculty Miyazaki of Medicine Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamasa","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Faculty Miyazaki of Medicine Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-4197","authenticated-orcid":false,"given":"Minako","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Faculty Miyazaki of Medicine Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-1510","authenticated-orcid":false,"given":"Michikazu","family":"Nakai","sequence":"additional","affiliation":[{"name":"Clinical Research Support Center University of Miyazaki Hospital Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-7630","authenticated-orcid":false,"given":"Masahiro","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Faculty Miyazaki of Medicine Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"341","article-title":"A Retrovirus Associated With Human Adult T\u2010Cell Leukemia: In\u00a0Vitro Activation","volume":"73","author":"Hinuma Y.","year":"1982","journal-title":"Gann"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90994-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-632489"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70161-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb02093.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-316794"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-757542"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2023.02.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_9_12_1","first-page":"522","article-title":"18F\u2010Fluoro\u2010Deoxyglucose Positron Emission Tomography for Post\u2010Treatment Evaluation of Malignant Lymphoma: A Systematic Review","volume":"91","author":"Zijlstra J. M.","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0494-8"},{"key":"e_1_2_9_14_1","first-page":"419","article-title":"FDG Accumulation in Tumor Tissue","volume":"34","author":"Kubota K.","year":"1993","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_15_1","first-page":"461","article-title":"Cellular Origin and Molecular Mechanisms of 18F\u2010FDG Uptake: Is There a Contribution of the Endothelium?","volume":"45","author":"Buck A. K.","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_16_1","first-page":"115","article-title":"Positron Emission Tomography With [18F] 2\u2010Fluoro\u2010D\u20102\u2010Deoxyglucose in Primary Cutaneous T\u2010Cell Lymphomas","volume":"89","author":"Valencak J.","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0924-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.5.577"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.072"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnm.0000134329.30912.49"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0822-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.905"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:56:12Z","timestamp":1764168972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/1346-8138.17867"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17867","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"2024-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}