{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:31:01Z","timestamp":1793313061465,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Epidermolysis bullosa (EB) is a severe genetic disorder marked by skin fragility and blistering from minimal trauma. Management relies on frequent and painful dressing changes. The EASE study (NCT03068780), the largest to date in EB, previously demonstrated accelerated wound healing and reduced wound burden for Oleogel\u2010S10 (birch triterpenes) versus control gel. This post hoc analysis focused on dressing change frequency and related time and cost savings among patients with daily dressing changes at baseline (Oleogel\u2010S10\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200947, control gel\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200953). By Day 90, 35.6% of Oleogel\u2010S10 patients required fewer daily changes versus 10.6% in the control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005). Weekly dressing changes reduced by 1.36\u2009\u00b1\u20090.24 with Oleogel\u2010S10 compared to 0.41\u2009\u00b1\u20090.23 for control (difference \u22120.95\u2009\u00b1\u20090.33;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005). This translated to almost three fewer dressing changes every 2\u2009weeks for Oleogel\u2010S10 versus nearly one change for the control gel. The estimated time saved per week was 10.7\u2009h with Oleogel\u2010S10 (6.4\u2009h patient, 4.3\u2009h caregiver) versus 4.0\u2009h with control (2.4\u2009h patient, 1.6\u2009h caregiver). Estimated dressing costs reduced by 59%, from $63.4\u2009k to $25.9\u2009k per patient over 27\u2009months. Oleogel\u2010S10 significantly reduced dressing frequency and time burden, with potential to ease the intensive demands of EB wound care.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17884","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T12:17:17Z","timestamp":1754050637000},"page":"1447-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reduction in Dressing Change Burden in Patients With Epidermolysis Bullosa\u2014Impact of Oleogel\u2010\n                    <scp>S10<\/scp>"],"prefix":"10.1111","volume":"52","author":[{"given":"Anna L.","family":"Bruckner","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2971-0199","authenticated-orcid":false,"given":"D\u00e9d\u00e9e","family":"Murrell","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St. George Hospital University of new South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-316X","authenticated-orcid":false,"given":"Lara Wine","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4093-1032","authenticated-orcid":false,"given":"Eli","family":"Sprecher","sequence":"additional","affiliation":[{"name":"The Tel Aviv Sourasky Medical Center, Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Kiritsi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Medical Center University of Freiburg  Freiburg Germany"},{"name":"First Department of Dermatology, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Maher","sequence":"additional","affiliation":[{"name":"Amryt Research Limited  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"L\u00f6we","sequence":"additional","affiliation":[{"name":"Chiesi GRD  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryanne","family":"Donovan","sequence":"additional","affiliation":[{"name":"Chiesi GRD  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes S.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Alfred Hospital, School of Translational Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EASE 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