{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:09:39Z","timestamp":1783037379915,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH\u201011104017"],"award-info":[{"award-number":["NCKUH\u201011104017"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Palmoplantar epidermal differentiation disorder associated with pachyonychia congenita (pEDD\u2010PC) is a rare autosomal dominant skin disorder caused by pathogenic variants in keratin genes, including\n KRT6A<\/jats:italic>\n ,\n KRT6B<\/jats:italic>\n ,\n KRT6C<\/jats:italic>\n ,\n KRT16<\/jats:italic>\n , and\n KRT17<\/jats:italic>\n . While statins have been reported to alleviate symptoms in\n KRT6A<\/jats:italic>\n \u2010pEDD\u2010PC, their efficacy in other subtypes remains unclear. We report six adult patients, including four with\n KRT17<\/jats:italic>\n variants and two with\n KRT16<\/jats:italic>\n variants, who underwent off\u2010label oral statin therapy. Statins were administered for at least 6\u2009months following dose stabilization. Although the treatment was well tolerated in most cases, no significant clinical improvement in plantar calluses or pain was observed. All patients discontinued therapy due to insufficient efficacy. Our findings indicate that oral statin therapy may offer limited benefit in\n KRT16<\/jats:italic>\n \/\n KRT17<\/jats:italic>\n \u2010pEDD\u2010PC and suggest the potential importance of early intervention and genotype\u2010specific therapeutic strategies.\n <\/jats:p>","DOI":"10.1111\/1346-8138.17900","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T09:54:29Z","timestamp":1754992469000},"page":"1608-1611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral Statin Therapy in\n KRT16<\/scp>\n \u2010 and\n KRT17<\/scp>\n \u2010Associated Palmoplantar Epidermal Differentiation Disorder (Pachyonychia Congenita)"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-0448","authenticated-orcid":false,"given":"Sota","family":"Itamoto","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-5859","authenticated-orcid":false,"given":"Wei\u2010Ting","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0075-0851","authenticated-orcid":false,"given":"Mika","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-5418","authenticated-orcid":false,"given":"Hideyuki","family":"Ujiie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4365-4533","authenticated-orcid":false,"given":"Chao\u2010Kai","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital Tainan Taiwan"},{"name":"International Center for Wound Repair and Regeneration (iWRR) National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-6366","authenticated-orcid":false,"given":"Ken","family":"Natsuga","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf054"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17276"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.41"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16393"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2008.08983.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18169"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.08.045"},{"key":"e_1_2_9_9_1","unstructured":"K.Wesley \u201cPalvella Therapeutics Reports Topline Results From Pivotal Phase 3 VAPAUS Study of QTORIN 3.9% Rapamycin Anhydrous Gel (QTORIN Rapamycin) for the Treatment of Pachyonychia Congenita.\u201d(2023) palvellatx.com\/2023\/07\/20\/palvella\u2010therapeutics\u2010reports\u2010topline\u2010results\u2010from\u2010pivotal\u2010phase\u20103\u2010vapaus\u2010study\u2010of\u2010qtorin\u2010rapamycin\u2010pachyonychia\u2010congenita."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.273"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13835"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/1543114"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.222"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.10.030"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051313"}],"container-title":["The Journal of 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