{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:01:51Z","timestamp":1764169311069,"version":"3.46.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Psoriatic arthritis (PsA) is a chronic inflammatory disease, with prevalence among psoriasis patients ranging from 6% to 42% across populations. Although targeted therapies such as adalimumab (ADA), secukinumab (SEC), and upadacitinib (UPA) have demonstrated efficacy in randomized controlled trials, real\u2010world head\u2010to\u2010head comparisons remain limited. This study aimed to compare the real\u2010world effectiveness and safety of ADA, SEC, and UPA in PsA patients. We conducted a prospective cohort study using data from the PARWCH database. PsA patients treated with ADA, SEC, or UPA were included and followed at baseline, Week 4, Week 12, and Week 24. Skin responses were evaluated using PASI75\/90. Joint outcomes\u2014including peripheral and axial arthritis\u2014were assessed with ACR, PsARC, and ASAS criteria. Patient\u2010reported pain, disease activity, and HAQ scores were also recorded. Adverse events (AEs) were monitored throughout treatment. MMRM and GLMM were used to analyze continuous and binary outcomes, respectively. A total of 187 PsA patients were included (SEC: 78; ADA: 66; UPA: 43). All three agents demonstrated comparable effectiveness in improving peripheral joint symptoms (ACR20: SEC vs. ADA, Coef\u2009=\u2009\u22120.29,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.62; UPA vs. ADA, Coef\u2009=\u2009\u22120.29,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.66) and axial involvement (ASAS20: SEC vs. ADA, Coef\u2009=\u2009\u22120.04,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.81; UPA vs. ADA, Coef\u2009=\u2009\u22121.05,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.23). UPA and SEC showed significantly greater effectiveness than ADA in improving skin lesions (PASI90: SEC vs. ADA, Coef\u2009=\u20091.84,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006; UPA vs. ADA, Coef\u2009=\u20091.53,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). However, ADA was more effective in relieving pain compared to both UPA (Coef\u2009=\u20092.43,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and SEC (Coef\u2009=\u20091.21,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Over 24\u2009weeks, 85 AEs were reported by 48 patients, with fatigue, rash, upper respiratory tract infection, and pruritus being the most common. No serious AEs occurred. In conclusion, UPA and SEC demonstrated balanced effectiveness across skin and joint domains, while ADA offered superior pain relief. These findings support personalized treatment strategies tailored to the clinical features of PsA patients.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17906","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T04:46:19Z","timestamp":1755492379000},"page":"1527-1535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Effectiveness and Safety of Adalimumab, Secukinumab, and Upadacitinib in Psoriatic Arthritis: A Prospective Cohort Study Based on\n                    <scp>PARWCH<\/scp>\n                    Cohort"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2205-1362","authenticated-orcid":false,"given":"Yiyi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-3560","authenticated-orcid":false,"given":"Jingya","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4835-4973","authenticated-orcid":false,"given":"Furong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyuan","family":"Li","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-9655","authenticated-orcid":false,"given":"Yue","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5006-6159","authenticated-orcid":false,"given":"Hongxiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiya","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-9122","authenticated-orcid":false,"given":"Dan","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-6066","authenticated-orcid":false,"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-5754","authenticated-orcid":false,"given":"Dengmei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Second University Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-2884","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rare Diseases Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00293-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.07.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002683"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0175-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"e081860","DOI":"10.1136\/bmj-2024-081860","article-title":"Advances in the Management of Psoriatic Arthritis in Adults","volume":"387","author":"Kharouf 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and Safety of Upadacitinib in Patients With Psoriatic Arthritis: 2\u2010Year Results From the Phase 3 SELECT\u2010PsA 1 Study","volume":"10","author":"McInnes I. B.","year":"2022","journal-title":"Rheumatology and Therapy"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002735"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-023-00589-3"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:56:15Z","timestamp":1764168975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,17]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/1346-8138.17906"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17906","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2025,8,17]]},"assertion":[{"value":"2025-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}