{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:38:46Z","timestamp":1773009526394,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A multicenter, open\u2010label, historically controlled, 2\u2010arm phase II study was conducted to evaluate the safety, efficacy, and pharmacokinetics of bexarotene in Japanese patients with adult T\u2010cell lymphoma\/leukemia (ATL). The study enrolled patients with indolent ATL and skin lesions and patients with aggressive ATL who had skin relapse after achieving remission following \u2265\u20091 regimen of systemic chemotherapy. Patients received oral bexarotene at an initial dose of 100\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (15 patients) or 300\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (17 patients) once daily for 24\u2009weeks. The 100\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    group included 14 patients with indolent ATL and 1 with aggressive ATL. The 300\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    group included 14 patients with indolent ATL and 3 with aggressive ATL. Of 12 patients in the 100\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    group, 6 patients achieved complete response (CR) or partial response (PR) as the best overall response (50.0%; 95% confidence interval (CI), 25.4%\u201374.6%). Of 17 patients in the 300\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    group, 12 patients achieved CR or PR (70.6%; 95% CI, 46.9%\u201386.7%) as estimated with the modified Severity Weighted Assessment Tool (mSWAT). Drug\u2010related adverse events (AEs) occurred in 15 patients (100%) in the 100\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    group and 16 of 17 patients (94.1%) in the 300\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    group. The most common AEs were hypothyroidism (75.1%) and hypertriglyceridemia (53.1%). This is the first report to evaluate the safety and efficacy of bexarotene in ATL focused on skin lesions. In both groups, the response rate exceeded the threshold defined for the study. Bexarotene might be effective in improving skin lesions in ATL of any type with good tolerability.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    This study was registered with the Japan Registry of Clinical Trials (jRCT2080224172)\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17919","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T08:31:15Z","timestamp":1755937875000},"page":"1619-1628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Open\u2010Label, Multicenter, Phase\n                    <scp>II<\/scp>\n                    Study of Bexarotene in Patients with Adult T\u2010Cell Leukemia\/Lymphoma"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-247X","authenticated-orcid":false,"given":"Kentaro","family":"Yonekura","sequence":"first","affiliation":[{"name":"Department of Dermatology Imamura General Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikko","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-2518","authenticated-orcid":false,"given":"Motoi","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Aoi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Kanekura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagoshima University School of Medicine  Kagoshima 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