{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T20:59:06Z","timestamp":1788641946665,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Panton\u2010Valentine leukocidin (PVL) is a toxin generally produced by community\u2010acquired methicillin\u2010resistant\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (CA\u2010MRSA) that is cytotoxic to neutrophils. USA300 is a virulent epidemic PVL\u2010producing MRSA clone; it is increasing. Recently, \u03a8USA300, a deleted mutant of USA300, has been identified in Japan. However, reports on the clinical and epidemiological characteristics of PVL\u2010producing MRSA strains, including USA300 and \u03a8USA300, remain limited. We included 65 patients who visited our dermatology clinic between January 2020 and May 2024 with skin and soft tissue infections in which CA\u2010MRSA was detected. Clinical information, antimicrobial susceptibility, PVL production, and MRSA strains were analyzed.PVL, found in 70.8% of patients with CA\u2010MRSA infection, was more common in younger patients (median age: 34\u2009years) without underlying diseases and was more likely to present with deep\u2010seated pyoderma (DSP), relapse of clinical symptoms, and intra\u2010familial outbreaks, with a sepsis\u2010related complication rate of 4.3%. Patients with PVL\u2010nonproducing MRSA were anemic and had renal dysfunction. USA300 accounted for 54.3% of the PVL\u2010producing CA\u2010MRSA, and 32.0% of USA300 strains were the \u03a8USA300 variant. All PVL\u2010producing CA\u2010MRSA strains were susceptible to rifampicin and minocycline, whereas most remained susceptible to sulfamethoxazole trimethoprim and fosfomycin. All USA300 strains, including \u03a8USA300 strains, were susceptible to gentamicin, whereas 44.4% of PVL\u2010producing non\u2010USA300 strains were susceptible.PVL\u2010producing CA\u2010MRSA infections commonly present with clinical manifestations of DSP, relapse of clinical symptoms, and intra\u2010familial outbreaks in younger individuals without underlying diseases and, rarely, with sepsis\u2010related complications. The increased incidence of USA300 and \u03a8USA300 strains in Japan, without differences in age, sex, clinical characteristics, clinical recurrence, intra\u2010familial outbreaks, and susceptibility to antibiotics, raises concerns regarding the possibility of the global spread of these infections. Given the susceptibility of these strains to gentamicin, nasal application of gentamicin may be a potential strategy to prevent intra\u2010familial outbreaks and the recurrence of USA300 strains, including \u03a8USA300.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17920","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T08:30:32Z","timestamp":1755937832000},"page":"1682-1690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Panton\u2010Valentine Leukocidin\u2010Producing Community\u2010Acquired Methicillin\u2010Resistant\n                    <scp>Staphylococcus aureus<\/scp>\n                    in Skin and Soft Tissue Infections: Clinical and Epidemiological Insights From Japan"],"prefix":"10.1111","volume":"52","author":[{"given":"Ayaka","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"},{"name":"Department of Dermatology Kawasaki Medical School General Medical Center  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Hatamiya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"},{"name":"Department of Dermatology Kawasaki Medical School General Medical Center  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3446-1211","authenticated-orcid":false,"given":"Hiroko","family":"Fukamatsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"},{"name":"Department of Dermatology Kawasaki Medical School General Medical Center  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-3750","authenticated-orcid":false,"given":"Seiko","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-7033","authenticated-orcid":false,"given":"Takenobu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"},{"name":"Department of Dermatology Kawasaki Medical School General Medical Center  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-5575","authenticated-orcid":false,"given":"Yumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.27"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2017.04.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.09.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/313461"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/427290"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2020.10.023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02272-21"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-010-0051-Y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.11.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01248-23"},{"key":"e_1_2_7_12_1","unstructured":"\u201cCLSI M100 Performance Standards for Antimicrobial Susceptibility Testing 35th Edition \u201dhttps:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2008.07.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0506-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15506"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-022-02636-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006387"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis468"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70238-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110908996"},{"key":"e_1_2_7_21_1","unstructured":"\u201cJapan Meteorological Agency \u201dhttps:\/\/www.data.jma.go.jp\/stats\/etrn\/index.php."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-24363-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2020.04.027"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.433"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055356"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042859"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.02.012"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68231-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-018-1336-z"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00054-15"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2015.03.007"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.0132"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.02932.x"},{"key":"e_1_2_7_34_1","first-page":"107","article-title":"Validation of a Phage\u2010Open Reading Frame Typing Kit for Rapid Identification of Methicillin\u2010Resistant Staphylococcus aureus (MRSA) Transmission in a Tertiary Hospital","volume":"8","author":"Takahashi H.","year":"2015","journal-title":"Infection and Drug Resistance"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.07.005"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03729-2"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.17920","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:52:28Z","timestamp":1773003148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/1346-8138.17920"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17920","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}