{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:38:31Z","timestamp":1773009511606,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bullous pemphigoid (BP) is the most common autoimmune blistering disease, predominantly affecting the elderly. Current treatments rely mainly on corticosteroids and immunosuppressive agents but are often limited by significant side effects. Omalizumab, an anti\u2010IgE monoclonal antibody, has emerged as a promising off\u2010label therapy for BP, but predictive markers for treatment response remain poorly understood. This study evaluates the efficacy and safety of omalizumab in BP and explores potential predictors of response, with a focus on tissue eosinophil counts. A retrospective analysis of 27 patients with severe BP treated with omalizumab was conducted. Complete remission (CR) was achieved in 63% of patients, partial remission (PR) in 18.5%, and no response\/flare\u2010up in 18.5%. The median total number of omalizumab doses was six (range 6\u201312), and 70.4% of patients received biweekly dosing. Notably, responders had significantly higher median tissue eosinophil counts (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.040) than non\u2010responders. No significant correlation was observed between treatment response and variables such as age, gender, disease duration, or blood eosinophil counts. Our findings suggest that tissue eosinophil levels may serve as a reliable predictor of omalizumab response in BP (\n                    <jats:italic>Z<\/jats:italic>\n                    \u2009=\u2009\u22122.034,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.040). Omalizumab demonstrated significant efficacy with minimal adverse effects, as only one patient reported a mild side effect (tickling sensation in the throat). While the study's single\u2010center design and small sample size limit generalizability, it provides valuable insights into potential predictive markers and supports omalizumab as a safe and effective treatment option for BP.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17932","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:03:09Z","timestamp":1756364589000},"page":"1691-1697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tissue Eosinophil Counts: A Promising Marker for Optimizing Omalizumab Treatment in Bullous Pemphigoid"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-4846","authenticated-orcid":false,"given":"G\u00fclfem","family":"Akin","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Sultanbeyli Public Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-2953","authenticated-orcid":false,"given":"Sevgi","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Dokuz Eylul University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-4960","authenticated-orcid":false,"given":"Ceylan","family":"Avc\u0131","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Dokuz Eylul University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-2664","authenticated-orcid":false,"given":"Banu","family":"Lebe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Dokuz Eylul University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-4663","authenticated-orcid":false,"given":"\u015eebnem","family":"Aktan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Dokuz Eylul University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-023-00832-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16791"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.928621"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.01.002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15946"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16678"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18220"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13547"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754221089267"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13164844"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad369"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.147"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17229"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12076"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07746-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-02909-1"},{"issue":"6","key":"e_1_2_11_18_1","first-page":"482","article-title":"Clinical Predictors of Polyps Recurring in Patients With Chronic Rhinosinusitis and Nasal Polyps: A Systematic Review and Meta\u2010Analysis","volume":"61","author":"Kim D. H.","year":"2023","journal-title":"Rhinology"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2020.01.005"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01919"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.17932","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:52:07Z","timestamp":1773003127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/1346-8138.17932"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17932","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"2025-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}