{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:38:42Z","timestamp":1773009522311,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lichen sclerosus et atrophicus (LSA) is a chronic, progressive inflammatory disorder with a risk of malignant transformation to squamous cell carcinoma (SCC). This study investigated the role of activation\u2010induced cytidine deaminase (AID) in UV\u2010independent SCC arising from LSA. We retrospectively analyzed 19 female patients, including 5 SCC cases. AID expression was significantly associated with SCC development, pruritus, and shorter disease duration. AID was detected in SCC lesions and adjacent LSA tissues, mainly in basal cells. Reduced AID expression was observed in higher\u2010stage tumors, suggesting its potential as a prognostic indicator. The use of topical corticosteroids was less common in AID\u2010positive patients, suggesting a possible association. These findings suggest a possible inverse association between topical corticosteroid use and AID expression.<\/jats:p>","DOI":"10.1111\/1346-8138.17935","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:17:19Z","timestamp":1758953839000},"page":"1732-1735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>AID<\/scp>\n                    Expression in Vulvar\n                    <scp>SCC<\/scp>\n                    Arising From Lichen Sclerosus et Atrophicus: A Retrospective Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4357-8005","authenticated-orcid":false,"given":"Hiroyuki","family":"Ito","sequence":"first","affiliation":[{"name":"The Department of Dermatology Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-2729","authenticated-orcid":false,"given":"Yohei","family":"Iwata","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Sugiura","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Arima","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-4592","authenticated-orcid":false,"given":"Kazumitsu","family":"Sugiura","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"790","article-title":"Du Lichen Plan et Particuli\u00e8rement de sa Forme Atrophique: Lichen Plan Scl\u00e9reux","volume":"8","author":"Hallopeau H.","year":"1887","journal-title":"Annales de Dermatologie et de Syphiligraphie"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"369","article-title":"Relation of Lichen Sclerosus et Atrophicus of the Vulva to Development of Carcinoma","volume":"45","author":"Hart W. 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