{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:59:52Z","timestamp":1792828792921,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015990","name":"Sanofi K.K.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic spontaneous urticaria (CSU) affects 0.5%\u20131.0% of the population worldwide. However, information on the prevalence, comorbidities, and treatment patterns of CSU in Japan is limited. This observational study consisted of a cross\u2010sectional and longitudinal part. The prevalence and incidence of CSU were estimated using the JMDC claims database (JMDC Inc., Tokyo, Japan). CSU was defined as either \u2018idiopathic urticaria\u2019, \u2018other urticaria\u2019 or \u2018unspecified urticaria\u2019 based on ICD\u201010 codes and prescribed H\n                    <jats:sub>1<\/jats:sub>\n                    \u2010antihistamines for \u2265\u20096\u2009weeks over a 3\u2010month period. Comorbidities, current treatments, and healthcare resource utilization in patients with CSU were also evaluated. The prevalence of CSU increased from 1.2% in 2016 to 1.6% in 2021 with a peak in children, while the incidence of CSU remained constant (0.7%\u20130.8%). Both prevalence and incidence were higher in females. Comorbid allergic rhinitis and conjunctivitis were frequent in the overall population, while comorbid asthma and atopic dermatitis were frequent in patients aged \u2264\u200911\u2009years. During the 1\u2010year observational period, approximately 95% of patients used H\n                    <jats:sub>1<\/jats:sub>\n                    \u2010antihistamines, followed by topical steroids, which are not recommended in the guidelines. Patients receiving the treatment in the same step as the initial month constituted the highest proportion represented during the following year. Oral corticosteroid use was relatively high, including in children, whereas omalizumab use was limited. The estimated recent prevalence and incidence of CSU in Japan were 1.6% and 0.8%, respectively. We also described patient characteristics and healthcare resource use. The present study encourages standardized practice for uncontrolled patients with CSU in Japan.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    UMIN Clinical Trials Registry: UMIN\u2010CTR 000051032\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17943","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T05:11:00Z","timestamp":1757394660000},"page":"1775-1787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence, Comorbidities, and Current Management of Chronic Spontaneous Urticaria in Japan: Retrospective Claims Database Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-8154","authenticated-orcid":false,"given":"Atsushi","family":"Fukunaga","sequence":"first","affiliation":[{"name":"Osaka Medical and Pharmaceutical University  Takatsuki Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kishi","sequence":"additional","affiliation":[{"name":"Sanofi K.K.  Shinjuku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Sunaga","sequence":"additional","affiliation":[{"name":"Sanofi K.K.  Shinjuku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0607-8787","authenticated-orcid":false,"given":"Kazuhiko","family":"Arima","sequence":"additional","affiliation":[{"name":"Sanofi K.K.  Shinjuku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02496.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15090"},{"issue":"10","key":"e_1_2_11_4_1","first-page":"1394","article-title":"Japanese Guidelines for Diagnosis and Treatment of Urticaria 2018","volume":"67","author":"Hide M.","year":"2018","journal-title":"Arerug\u012b"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16562"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14041162"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14502"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13102967"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20165071"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1168.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.03.047"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2022.09.003"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgf2.422"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-RAI-0497"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14037"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14075"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12910"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.064"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2024.12.008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00389-z"},{"issue":"3","key":"e_1_2_11_21_1","first-page":"214","article-title":"Epidemiology of Urticaria in Spain","volume":"14","author":"Gaig P.","year":"2004","journal-title":"Journal of Investigational Allergology and Clinical Immunology"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.1008145"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.03.033"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2023.100159"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14210"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2018.39.4166"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12870"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13209"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.02.005"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14947"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2022.43.220068"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.2056"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.08.014"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T06:34:53Z","timestamp":1768026893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/1346-8138.17943"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17943","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]},"assertion":[{"value":"2024-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}