{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:30:43Z","timestamp":1785364243741,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Long\u2010term (2\u2010year) effectiveness of bimekizumab for psoriasis is unknown in real\u2010world practice. This study is aimed at evaluating 104\u2010week real\u2010world effectiveness of bimekizumab in patients with psoriasis, stratified by the presence or absence of prior biologic treatment. From May 2022 to May 2025, we prospectively assessed 66 Japanese patients With psoriasis who received bimekizumab 320\u2009mg every 4\u2009weeks (Q4W) until week 16, thereafter Q4W (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928) or Q8W (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200938) assigned based on patients' preference. Both Q4W and Q8W bimekizumab regimens rapidly decreased the psoriasis area and severity index (PASI) to approximately 0 by week 16, which was sustained through week 104. The speed of achieving PASI 90, 100, or static physician's global assessment (sPGA) 0\/1 was faster for biologic\u2010experienced patients compared to na\u00efve ones in the Q4W regimen while faster for biologic\u2010na\u00efve patients in the Q8W regimen. The above achievement rates in biologic\u2010na\u00efve patients were maintained through week 104 while those in biologic\u2010experienced patients slightly reduced later than week 68 or 92 in the Q4W or Q8W regimen, respectively. Taken together, Q4W and Q8W treatment with bimekizumab rapidly improved symptoms of psoriasis, and the improvement was mostly maintained through week 104. The achievement rates of PASI 90, 100, or sPGA 0\/1 were mostly sustained through week 104 in biologic\u2010na\u00efve patients while slightly reduced in biologic\u2010experienced patients at later phases of treatment.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17962","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T09:30:12Z","timestamp":1758187812000},"page":"1856-1863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A 104\u2010Week Real\u2010World Outcome of Bimekizumab Treatment for Psoriasis: Biologic\u2010Na\u00efve Versus \u2010Experienced Patients"],"prefix":"10.1111","volume":"52","author":[{"given":"Yohei","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-2312","authenticated-orcid":false,"given":"Naoko","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai 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