{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:08:07Z","timestamp":1783339687975,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012033","name":"Japanese Dermatological Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Merkel cell carcinoma (MCC) is a highly malignant skin cancer characterized by high rates of recurrence and metastasis. Although rare, the incidence has noticeably increased in recent years. It is also known to be a highly immunogenic tumor, and the use of immune checkpoint inhibitors has begun for advanced cases. However, there had been no guidelines for this disease in Japan. Commissioned by the Japanese Dermatological Association (JDA), this revision was undertaken by a committee comprising experts across relevant fields, who meticulously reviewed and systematized a wide range of literature on MCC to create comprehensive, evidence\u2010based guidelines. Literature searches were conducted by the Japan Medical Library Association. The recommendation statements were determined using the GRADE Grid approach. The guidelines were developed in accordance with the \u201cMinds Clinical Practice Guideline Creation Manual 2020 ver.3.0.\u201d Four clinical questions (CQs) were established, and corresponding recommendation statements were provided for each. CQ1 concerns primary tumor resection margins, CQ2 concerns sentinel lymph node biopsy, CQ3 concerns postoperative radiotherapy, and CQ4 concerns chemotherapy for advanced disease. These guidelines are the first of their kind in Japan for MCC, and we hope that they will be useful not only in Japan but also in East Asia, where treatment decisions have previously had to be made based on Western guidelines.<\/jats:p>","DOI":"10.1111\/1346-8138.17974","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:02:27Z","timestamp":1759917747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-7782","authenticated-orcid":false,"given":"Motoki","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Nagase","sequence":"additional","affiliation":[{"name":"Nagase Dermatology Clinic  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-640X","authenticated-orcid":false,"given":"Masahito","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuo","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadahiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Public Central Hospital of Matto Ishikawa  Matto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-3984","authenticated-orcid":false,"given":"Akihiko","family":"Yuki","sequence":"additional","affiliation":[{"name":"Division of Dermatology Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2526-3504","authenticated-orcid":false,"given":"Hiroshi","family":"Uchi","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology National Hospital Organization Kyushu Cancer Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-8037","authenticated-orcid":false,"given":"Hiroshi","family":"Koga","sequence":"additional","affiliation":[{"name":"Kitatoda Alps Dermatology Clinic  Toda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-3128","authenticated-orcid":false,"given":"Tomomitsu","family":"Miyagaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology St. Marianna University School of Medicine  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-017-9433-0"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.028"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15823"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16232"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5266-4"},{"key":"e_1_2_16_7_1","unstructured":"T.Morizane A.Okumura Y.Sato T.Baba T.Fukuoka andM.Yoshida Minds Clinical Practice Guideline Development Manual 2020. 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