{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:29:35Z","timestamp":1773419375918,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Psoriasis is a chronic, immune\u2010mediated inflammatory condition primarily involving the skin but increasingly recognized to affect multiple organ systems. Emerging evidence has drawn attention to its potential association with ophthalmic comorbidities, notably dry eye syndrome (DES), keratoconus, and cataract. To determine the prevalence of DES, keratoconus, and cataract in individuals with moderate\u2010to\u2010severe psoriasis compared with matched healthy controls. A retrospective case\u2013control study was conducted involving the review of medical records from 150 patients with psoriasis and 150 age\u2010 and sex\u2010matched control subjects. Ophthalmic diagnoses were ascertained using ICD\u201010 coding and clinical documentation. Multivariable logistic regression was employed to evaluate the independent association between psoriasis and ocular conditions. The prevalence of keratoconus and DES was significantly higher in the psoriasis cohort than in controls (10.0% vs. 2.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0178; 18.0% vs. 8.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0272, respectively). Although cataract was more frequent among psoriasis patients (4.0% vs. 0.7%), the difference did not reach statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.1261). Psoriasis was independently associated with keratoconus (OR 4.03; 95% CI, 1.3\u201312.5) and DES (OR 2.31; 95% CI, 1.14\u20134.68). Subgroup analysis revealed a notably higher prevalence of keratoconus in female patients with psoriasis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0159). These findings suggest that psoriasis may be associated with an increased likelihood of specific ocular conditions, particularly keratoconus and DES. The sex\u2010related disparity observed in keratoconus prevalence warrants further investigation into possible hormonal factors, including the potential role of estrogen\u2010mediated corneal changes. Routine ophthalmological evaluation could be considered as part of comprehensive care in patients with psoriasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1346-8138.17977","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:30:26Z","timestamp":1759149026000},"page":"94-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ocular Comorbidities in Psoriasis: A Retrospective Study on Dry Eye Syndrome, Keratoconus, and Cataract Development"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4462-6526","authenticated-orcid":false,"given":"Se\u00e7il Yigen","family":"\u0130R\u0130TA\u015e","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereal Diseases Pendik Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lter","family":"\u0130R\u0130TA\u015e","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Pendik State Hospital  Istanbul Turkey"},{"name":"Department of Ophthalmology St. Mary's Hospital Isle of Wight NHS Trust  Newport Isle of Wight UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010010\u20101080\u20101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010022\u201002488\u2010z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.064"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130457"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000522167"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/11206721211007096"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002161"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19773"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.16261"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792\u2010022\u201002320\u20107"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106206"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2021.101559"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040913"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101812010181"},{"issue":"1","key":"e_1_2_9_16_1","first-page":"50","article-title":"Lens metabolizmas\u0131 ve katarakt geli\u015fim mekanizmalar\u0131","volume":"6","author":"Karel F.","year":"1997","journal-title":"Turkiye Klinikleri Journal of Ophthalmology"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103142"},{"issue":"1","key":"e_1_2_9_18_1","first-page":"3","article-title":"Hastal\u0131k \u015fiddetinin tan\u0131mlanmas\u0131","volume":"56","author":"B\u00fclb\u00fcl Ba\u015fkan E.","year":"2022","journal-title":"Turkderm\u2010Deri Hastaliklari Ve Frengi Arsivi"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60091458"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12183"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.08.021"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2020.07.016"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12174"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792\u2010024\u201003147\u20100"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgf2.576"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_551_22"},{"key":"e_1_2_9_27_1","first-page":"369","volume-title":"T\u00fcm Y\u00f6nleriyle Psoriasis","author":"Balc\u0131 D. D.","year":"2020"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.05.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S256629"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2022.11.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002150"},{"key":"e_1_2_9_32_1","first-page":"1","article-title":"Clinical and Epidemiological Features of Keratoconus Genetic and External Factors in the Pathogenesis of the Disease","volume":"178","author":"Ihalainen A.","year":"1986","journal-title":"Acta Ophthalmologica. Supplementum"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14082"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12147"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102017\u2010311391"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286586.2020.1804593"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000000669"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201023\u20101906"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182068adc"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/11206721211045187"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.5935\/0004\u20102749.20180044"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10413"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2021.104272"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.110122"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.17977","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:16:13Z","timestamp":1773411373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1346-8138.17977"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17977","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}