{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T14:42:44Z","timestamp":1768056164284,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    High\u2010dose radiotherapy is the standard treatment for cutaneous angiosarcoma (CAS); however, adverse events and organ toxicity remain major challenges. Intensity\u2010modulated radiation therapy using tomotherapy allows the precise targeting of complex lesions. We retrospectively reviewed 12 patients with CAS who were treated with tomotherapy and paclitaxel between January 2017 and April 2024. Clinical outcomes, including progression\u2010free survival, overall survival, and adverse events, were analyzed and compared with those of the historical controls. The median progression\u2010free survival was 10.5\u2009months (95% confidence interval: 7.7\u2013not reached). The 2\u2010year overall survival and progression\u2010free survival rates were 70.0% and 41.7%, respectively. Grade \u2265\u20093 adverse events occurred in a limited number of patients, including radiation\u2010induced dermatitis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091), neutropenia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), peripheral neuropathy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091), and corneal toxicity (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091). Nevertheless, the treatment regimen was generally well tolerated and achieved favorable survival outcomes, representing a safe and effective treatment option.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17981","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:48:56Z","timestamp":1759484936000},"page":"1888-1891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Helical Tomotherapy Combined With Paclitaxel in Cutaneous Angiosarcoma"],"prefix":"10.1111","volume":"52","author":[{"given":"Megumi","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Oncology NHO Kagoshima Medical Center  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-8953","authenticated-orcid":false,"given":"Kazuyasu","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology NHO Kagoshima Medical Center  Kagoshima Japan"},{"name":"Department of Dermatology Kindai University Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-247X","authenticated-orcid":false,"given":"Kentaro","family":"Yonekura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Imamura General Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Radiology Imamura General Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5804-4060","authenticated-orcid":false,"given":"Masashi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology NHO Kagoshima Medical Center  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Tozawa","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology NHO Kagoshima Medical Center  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokiyoshi","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology NHO Kagoshima Medical Center  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-5341","authenticated-orcid":false,"given":"Shigeto","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology NHO Kagoshima Medical Center  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1090168"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00046"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.627113"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16273"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-023-02093-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028210"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16110"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13110"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrad089"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T06:34:51Z","timestamp":1768026891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/1346-8138.17981"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17981","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"assertion":[{"value":"2025-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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