{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:29:35Z","timestamp":1773419375728,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Pruritic lesions, including prurigo nodularis (PN), represent chronic and often refractory disease. Existing severity scorings for\n PN<\/jats:styled-content>\n are challenging to use effectively and need improvement to accurately assess disease severity and treatment efficacy. Additionally, effective treatment options for\n PN<\/jats:styled-content>\n remain limited. To assess the correlation between existing and newly proposed severity scorings, evaluate the usefulness of these new severity scorings, and review the treatment outcomes in patients with\n PN.<\/jats:styled-content>\n This study included 22 patients with\n PN<\/jats:styled-content>\n . As newly proposed severity scorings, we tested the number (termed the \u201cbreaking\u2010number\u201d) and the rate (termed the \u201cbreaking\u2010rate\u201d) of nodules on the state of \u201cself\u2010destruction (erosion or ulcer)\u201d as a result of scratching due to severe itching. Spearman's correlation coefficient was used to assess the correlations. We also had statistics on the correlation between these severity scorings and some blood test findings (serum thymus and activation regulated chemokine levels, serum immunoglobulin E levels, serum lactate dehydrogenase levels, the blood eosinophil count, and the blood basophil count). The breaking\u2010number correlated with the Worst Itching Intensity Numerical Rating Scale (\n WI<\/jats:styled-content>\n \u2010\n NRS<\/jats:styled-content>\n ) and Investigators Global Assessment for\n PN<\/jats:styled-content>\n Stage (\n IGA PN<\/jats:styled-content>\n \u2010S) scores (\n p<\/jats:italic>\n <\u20090.05), and the breaking\u2010rate correlated with\n WI<\/jats:styled-content>\n \u2010\n NRS<\/jats:styled-content>\n score (\n p<\/jats:italic>\n <\u20090.05), but not with\n IGA PN<\/jats:styled-content>\n \u2010S score (\n p<\/jats:italic>\n \u2009\u2265\u20090.05). Only the blood basophil count correlated with the breaking\u2010number, breaking\u2010rate, and the\n IGA PN<\/jats:styled-content>\n \u2010S score (\n p\u2009<<\/jats:italic>\n \u20090.05). The breaking\u2010number and breaking\u2010rate could be used to assess the severity of\n PN<\/jats:styled-content>\n . We hope these severity scorings will lead to quick and accurate assessment of disease severity and treatment efficacy.\n <\/jats:p>","DOI":"10.1111\/1346-8138.70005","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:05:51Z","timestamp":1759917951000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severity Scorings for Prurigo Nodularis With Review of Treatment Outcome in 22 Cases"],"prefix":"10.1111","volume":"53","author":[{"given":"Rikuma","family":"Kitao","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiharu","family":"Kubo","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-711X","authenticated-orcid":false,"given":"Takeshi","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"},{"name":"Department of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1607","article-title":"The Japanese Dermatological Association Guideline: Guideline for Clinical Practice of Chronic Prurigo","volume":"130","author":"Satoh T.","year":"2020","journal-title":"Japanese Journal of Dermatology"},{"key":"e_1_2_10_3_1","first-page":"107","article-title":"Skin Disease in Lambeth. A Community Study of Prevalence and Use of Medical Care","volume":"30","author":"Rea J. N.","year":"1976","journal-title":"British Journal of Preventive & Social Medicine"},{"key":"e_1_2_10_4_1","first-page":"1795","article-title":"Nationwide Cross\u2010Sectional and Seasonal Multicenter Study of Dermatological Patients in Japan","volume":"119","author":"Furue M.","year":"2009","journal-title":"Japanese Journal of Dermatology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555577231234"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15212"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02320-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/jom-2023-0125"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1092685"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13030878"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13040634"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15040"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20103701"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.01.036"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-023-00818-z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18377"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8606"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S354025"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14279"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae131"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2023.06.005"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:16:09Z","timestamp":1773411369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1346-8138.70005"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70005","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"2025-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}