{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:56:40Z","timestamp":1792792600903,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n We report two cases of folliculosebaceous poroma (holocrine poroma) harboring gene rearrangements involving members of the p21\u2010activated kinase (\n PAK<\/jats:italic>\n ) family. Both tumors were composed of small poroid cells with ductal and sebaceous differentiation and demonstrated strong nuclear GATA3 expression on immunostaining. In one case, fluorescence in\u00a0situ hybridization (FISH) demonstrated a\n PAK2<\/jats:italic>\n rearrangement; in the other, a\n PAK3<\/jats:italic>\n rearrangement was identified. Although GATA3 has been proposed as a useful marker to distinguish clonal seborrheic keratosis from hidroacanthoma simplex, its strong expression in\n PAK2\/PAK3<\/jats:italic>\n \u2010rearranged folliculosebaceous poromas suggests limited specificity in this differential context. Notably, to our knowledge, this represents the first reported case of a benign poroma harboring a\n PAK3<\/jats:italic>\n rearrangement. These findings support a role for\n PAK<\/jats:italic>\n gene fusions that may contribute to sebaceous differentiation in folliculosebaceous poroma and underscore the molecular heterogeneity of poromas.\n <\/jats:p>","DOI":"10.1111\/1346-8138.70014","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:41:36Z","timestamp":1760442096000},"page":"1902-1905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Folliculosebaceous Poromas With\n PAK2<\/scp>\n and\n PAK3<\/scp>\n Rearrangements: A Report of Two Cases and Review of the Literature"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7603-5088","authenticated-orcid":false,"given":"Shuji","family":"Suzuki","sequence":"first","affiliation":[{"name":"Takadanobaba Dermatology & Plastic Surgery Shinjukuku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hyogo Cancer Center Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kajimoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hyogo Cancer Center Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Adachi","sequence":"additional","affiliation":[{"name":"Kaneki Dermatology Clinic Iwaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-6142","authenticated-orcid":false,"given":"Takaya","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Fukumoto Dermatopathology Clinic Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126185"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001046"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31815f2ae3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20100960.2009.00596.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14940"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15214"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.641381"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4161\/cl.21912"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.119"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746\u20101596\u20109\u201055"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000306"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001998"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002503"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T06:34:41Z","timestamp":1768026881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/1346-8138.70014"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70014","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"assertion":[{"value":"2025-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}