{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:38:05Z","timestamp":1790181485797,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neurofibromatosis 1 (NF1) is a multisystem genetic disorder characterized by cutaneous, neurological, and skeletal manifestations. Plexiform neurofibroma (PN) is a benign peripheral nerve sheath tumor, often leading to considerable morbidity due to its progressive nature. Selumetinib, a MEK inhibitor, represents a novel therapeutic agent for the treatment of symptomatic, inoperable PNs in pediatric NF1 patients. This report presents NF1 cases managed at Tottori University Hospital, in which the clinical application of selumetinib was evaluated under the guidance of institutional advisory boards and coordinated by a multidisciplinary team (MDT). Treatment with selumetinib resulted in clinical benefits, accompanied by manageable adverse events such as acneiform rash and transient elevations in serum creatine kinase levels. The coordinated efforts of the MDT facilitated appropriate patient selection, individualized dose adjustments, effective management of adverse events, and long\u2010term follow\u2010up. These cases highlight the clinical utility of selumetinib and underscore the importance of MDT involvement in the management of pediatric NF1 patients with PNs in Japan.<\/jats:p>","DOI":"10.1111\/1346-8138.70030","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:17:32Z","timestamp":1761218252000},"page":"135-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multidisciplinary Management of Plexiform Neurofibromas in Pediatric Patients With Neurofibromatosis 1: Insights From Advisory Board\u2010Guided Clinical Experience in Japan"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8865-820X","authenticated-orcid":false,"given":"Yuko","family":"Ehara","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine of Sensory and Motor Organs Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-2236","authenticated-orcid":false,"given":"Tohru","family":"Okanishi","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Brain and Neurosciences Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-9534","authenticated-orcid":false,"given":"Yoshiko","family":"Suyama","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-6528","authenticated-orcid":false,"given":"Kensaku","family":"Yamaga","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Surgery, Department of Sensory and Motor Organs Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-7517","authenticated-orcid":false,"given":"Masanobu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Perinatology Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-945X","authenticated-orcid":false,"given":"Ryoya","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Multidisciplinary Internal Medicine Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-4142","authenticated-orcid":false,"given":"Hiroyuki","family":"Awano","sequence":"additional","affiliation":[{"name":"Organization for Research Initiative and Promotion Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomki","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Division of Clinical Genetics Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Miyake","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology and Visual Science Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-8427","authenticated-orcid":false,"given":"Takahiro","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-5915","authenticated-orcid":false,"given":"Atsushi","family":"Kambe","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Brain and Neurosciences Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Depertment of Pharmacy Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-7337","authenticated-orcid":false,"given":"Yuichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine of Sensory and Motor Organs Faculty of Medicine, Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.2023\u20100013\u2010IR"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010021\u201001170\u20105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102979"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2020.3937"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912735"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201016560\u20103"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201091455\u20105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101818"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70100\u20108"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad099"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010023\u201010914\u20102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S453275"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:16:40Z","timestamp":1773411400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1346-8138.70030"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70030","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]},"assertion":[{"value":"2025-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}